Properdin: A multifaceted molecule involved in inflammation and diseases.
Properdin: A multifaceted molecule involved in inflammation and diseases.
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DOI：
10.1016/j.molimm.2018.05.018
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发表时间：
2018-10
影响因子：
3.6
通讯作者：
Ferreira VP
中科院分区：
文献类型：
--
作者：
Chen JY;Cortes C;Ferreira VP
备解素是广为人知的替代途径(AP)的正向调节因子，在过去的十年中进行了大量的研究，以确定其在炎症和疾病中的功能，包括它在关节炎、哮喘以及肾脏和心血管疾病中的作用。备解素是一种存在于血浆中的糖蛋白，主要由白细胞产生，通过稳定C3和C5转换酶并启动AP来正向调节AP的活性。备解素对补体活性的促进作用导致细胞微环境的改变，这些微环境有助于先天和获得性免疫反应，包括促炎细胞因子的产生、免疫细胞的渗透、抗原提呈细胞的成熟和组织损伤。利用缺乏备解素的小鼠模型和中和抗体有助于理解备解素促进或预防疾病病理的机制。本文主要综述了备解素在炎症和疾病中的多方面作用，以及了解这些作用如何有助于开发新的疾病治疗方法。
Properdin, the widely known positive regulator of the alternative pathway (AP), has undergone significant investigation over the last decade to define its function in inflammation and disease, including its role in arthritis, asthma, and kidney and cardiovascular diseases. Properdin is a glycoprotein found in plasma that is mainly produced by leukocytes and can positively regulate AP activity by stabilizing C3 and C5 convertases and initiating the AP. Promotion of complement activity by properdin results in changes in the cellular microenvironment that contribute to innate and adaptive immune responses, including pro-inflammatory cytokine production, immune cell infiltration, antigen presenting cell maturation, and tissue damage. The use of properdin-deficient mouse models and neutralizing antibodies has contributed to the understanding of the mechanisms by which properdin contributes to promoting or preventing disease pathology. This review mainly focusses on the multifaceted roles of properdin in inflammation and diseases, and how understanding these roles is contributing to the development of new disease therapies.
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