Serum prolactin levels and sexual dysfunction in patients with schizophrenia treated with antipsychotics: comparison between aripiprazole and other atypical antipsychotics.
Serum prolactin levels and sexual dysfunction in patients with schizophrenia treated with antipsychotics: comparison between aripiprazole and other atypical antipsychotics.
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DOI：
10.1186/s12991-017-0166-y
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发表时间：
2017
影响因子：
3.7
通讯作者：
Kirino E
中科院分区：
文献类型：
--
作者：
Kirino E
抗精神病药物，即使是非典型的，可以诱导高泌乳素血症。阿立哌唑（APZ）是一种多巴胺D2部分激动剂，具有独特的药理作用，副作用少。我们调查了接受APZ和其他抗精神病药物治疗的精神分裂症患者高泌乳素血症的发生率。血清催乳素水平测定ELISA（酶联免疫吸附试验）。采用问卷调查的方法评价主观性功能障碍。根据调查问卷的结果，大约一半（48.1%）的患者抱怨性功能障碍。有性功能障碍者血清催乳素水平明显高于无性功能障碍者。在接受抗精神病药单药治疗的患者中，接受APZ治疗的患者血清催乳素水平显著低于接受其他抗精神病药治疗的患者。在接受2种或2种以上抗精神病药物治疗的患者中，接受含APZ方案治疗的患者血清催乳素水平显著低于接受无APZ方案治疗的患者。APZ治疗不影响血清催乳素水平，APZ连续治疗可改善与其他抗精神病药单药治疗期间发生的高催乳素血症。
Antipsychotics, even atypical ones, can induce hyperprolactinemia. Aripiprazole (APZ), a dopamine D2 partial agonist, has a unique pharmacological profile and few side effects. We investigated the incidence of hyperprolactinemia in patients with schizophrenia treated with APZ and other antipsychotics. Serum prolactin levels were measured by ELISA (enzyme-linked immunosorbent assay). A questionnaire survey was used to evaluate subjective sexual dysfunction. Based on the results of the questionnaire, approximately half (48.1%) of the patients complained of sexual dysfunction. The serum prolactin levels were significantly higher in patients with sexual dysfunction than in those without. In patients treated with antipsychotic monotherapy, the serum prolactin levels were significantly lower in patients treated with APZ than with other antipsychotics. In patients receiving 2 or more antipsychotics, the serum prolactin levels were significantly lower in patients treated with APZ-containing regimens than in patients treated with APZ-free regimens. Treatment with APZ did not influence the serum prolactin level, and adjunctive treatment with APZ may ameliorate the hyperprolactinemia that occurs during monotherapy with other antipsychotics.
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