Diversity of mechanisms involved in aromatase regulation and estrogen action in the brain.
Diversity of mechanisms involved in aromatase regulation and estrogen action in the brain.
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DOI：
10.1016/j.bbagen.2009.12.010
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Balthazart J
中科院分区：
文献类型：
--
作者：
Charlier TD;Cornil CA;Ball GF;Balthazart J
近年来，雌激素调节神经元生理学、脑形态学和行为的机制已被证明比以前认为的要复杂得多。例如，第二个核雌激素受体已被确定，一个新的家族的共调节蛋白调节类固醇依赖性基因转录被发现，最后，它已经变得清楚，雌激素有令人惊讶的快速影响的基础上，他们的行动对细胞膜，这反过来又导致在细胞内信号级联的调制。本文提出了一个选择性审查的新发现在这方面的工作在我们的实验室，侧重于雌激素的作用，在男性性行为的激活。两个独立的主题被认为是。我们首先讨论类固醇受体辅激活因子-1（SRC-1）的功能，它已成为雌二醇行为效应的关键限制因素。通过反义寡核苷酸敲低其表达可显著抑制雄性典型的性行为。其次，我们描述了快速调节脑雌二醇生产的钙依赖性磷酸化的芳香化酶，本身的神经递质活性的控制下。雌激素生物利用度的这些快速变化具有明显的行为后果。分别通过急性注射雌二醇本身或芳香酶抑制剂获得的雌二醇浓度的增加或减少在15-30分钟内导致性行为频率的平行变化。雌激素作用的这些新的控制提供了雌激素作用的离散局部控制的大量可能性。它们也代表了一个艰巨的挑战，神经内分泌学家试图获得一个综合的观点，大脑功能的行为。
The mechanisms through which estrogens modulate neuronal physiology, brain morphology, and behavior in recent years have proven to be far more complex than previously thought. For example, a second nuclear estrogen receptor has been identified, a new family of coregulatory proteins regulating steroid-dependent gene transcriptions was discovered and, finally, it has become clear that estrogens have surprisingly rapid effects based on their actions on cell membranes, which in turn results in the modulation of intracellular signaling cascades. This paper presents a selective review of new findings in this area related to work in our laboratories, focusing on the role of estrogens in the activation of male sexual behavior. Two separate topics are considered. We first discuss functions of the steroid receptor coactivator-1 (SRC-1) that has emerged as a key limiting factor for behavioral effects of estradiol. Knocking-down its expression by antisense oligonucleotides drastically inhibits male-typical sexual behaviors. Secondly, we describe rapid regulations of brain estradiol production by calcium-dependent phosphorylations of the aromatase enzyme, themselves under the control of neurotransmitter activity. These rapid changes in estrogen bioavailability have clear behavioral consequences. Increases or decreases in estradiol concentrations respectively obtained by an acute injection of estradiol itself or of an aromatase inhibitor lead within 15-30 min to parallel changes in sexual behavior frequencies. These new controls of estrogens action offer a vast array of possibilities for discrete local controls of estrogen action. They also represent a formidable challenge for neuroendocrinologists trying to obtain an integrated view of brain function in relation to behavior.
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影响因子：
4.8
作者：
Balthazart, J;Baillien, M;Ball, GF
通讯作者：
Ball, GF
影响因子：
3.4
作者：
Balthazart, J;Baillien, M;Ball, GF
通讯作者：
Ball, GF
影响因子：
3.5
作者：
BALTHAZART, J;EVRARD, L;SURLEMONT, C
通讯作者：
SURLEMONT, C
影响因子：
3.3
作者：
Charlier, T. D.;Ball, G. F.;Balthazart, J.
通讯作者：
Balthazart, J.
影响因子：
3.3
作者：
Chaban, VV;Mayer, EA;Micevych, PE
通讯作者：
Micevych, PE