Associations between air pollution and peak expiratory flow among patients with persistent asthma.
Associations between air pollution and peak expiratory flow among patients with persistent asthma.
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DOI：
10.1080/15287390802445517
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Bascom R
中科院分区：
文献类型：
--
作者：
Qian Z;Lin HM;Chinchilli VM;Lehman EB;Stewart WF;Shah N;Duan Y;Craig TJ;Wilson WE;Liao D;Lazarus SC;Bascom R
持续性哮喘患者对环境空气污染的反应可能不同于一般人群。例如，哮喘药物可能会改变环境空气污染物对呼气峰流量（PEF）的影响。很少有研究使用哮喘临床试验数据，在接受明确药物治疗方案的持续性哮喘患者中检查空气污染与PEF之间的关系。在沙美特罗非皮质类固醇研究试验中，154例持续性哮喘患者在16周的积极治疗期间，使用14，919人-天的每日自测呼气峰流量（PEF）评估了环境空气污染物的气道阻塞效应。这三种疗法分别是吸入性皮质类固醇、吸入性长效β受体激动剂和安慰剂。参与者是1997年2月至1999年1月从6所大学门诊护理中心招募的年龄在12岁至63岁之间的不吸烟者。空气污染数据来自美国环境保护局的大气信息检索系统。在校正了年龄、性别、人种/种族、哮喘临床中心、季节、周、日平均温度和日平均相对湿度的模型中，NO2的环境日平均浓度增加10 ppb与PEF降低1.53 L/min（95%置信区间[CI]-2.93至0.14）相关。在接受沙美特罗治疗的患者中观察到NO2与PEF之间的最强关联。PEF与SO2和PM10之间也分别存在负相关性。结果表明，这两种药物方案保护免受PM10的影响。而沙美特罗增加了对NO2的敏感性，曲安奈德增加了对SO2的敏感性。
Responses of patients with persistent asthma to ambient air pollution may be different from those of general populations. For example, asthma medications may modify the effects of ambient air pollutants on peak expiratory flow (PEF). Few studies examined the association between air pollution and PEF in patients with persistent asthma on well-defined medication regimens using asthma clinical trial data. Airway obstruction effects of ambient air pollutants, using 14,919 person-days of daily self-measured peak expiratory flow (PEF), were assessed from 154 patients with persistent asthma during the 16 wk of active treatment in the Salmeterol Off Corticosteroids Study trial. The three therapies were an inhaled corticosteroid, an inhaled long-acting β-agonist, and placebo. The participants were nonsmokers aged 12 through 63 yr, recruited from 6 university-based ambulatory care centers from February 1997 to January 1999. Air pollution data were derived from the U.S. Environmental Protection Agency Aerometric Information Retrieval System. An increase of 10 ppb of ambient daily mean concentrations of NO2 was associated with a decrease in PEF of 1.53 L/min (95% confidence interval [CI] −2.93 to −0.14) in models adjusted for age, gender, race/ethnicity, asthma clinical center, season, week, daily average temperature, and daily average relative humidity. The strongest association between NO2 and PEF was observed among the patients treated with salmeterol. Negative associations were also found between PEF and SO2 and between PEF and PM10, respectively. The results show that the two medication regimens protected against the effects of PM10. However, salmeterol increased the sensitivity to NO2 and triamcinalone enhanced the sensitivity to SO2.
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影响因子：
10.4
作者：
Delfino RJ;Zeiger RS;Seltzer JM;Street DH;McLaren CE
通讯作者：
McLaren CE
影响因子：
5.4
作者：
Rosenlund, Mats;Picciotto, Sally;Perucci, Carlo A.
通讯作者：
Perucci, Carlo A.
DOI：
10.1164/ajrccm.159.3.9804144
发表时间：
1999-03-01
影响因子：
24.7
作者：
Peters, JM;Avol, E;Thomas, DC
通讯作者：
Thomas, DC
影响因子：
10.4
作者：
Peters, A;Dockery, DW;Wichmann, HE
通讯作者：
Wichmann, HE
DOI：
10.1164/ajrccm/144.3_pt_1.668
发表时间：
1991-09-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
POPE, CA;DOCKERY, DW;RAIZENNE, ME
通讯作者：
RAIZENNE, ME