Selective prefrontal serotonin depletion impairs acquisition of a detour-reaching task.
Selective prefrontal serotonin depletion impairs acquisition of a detour-reaching task.
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DOI：
10.1111/j.1460-9568.2006.04826.x
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发表时间：
2006-06
期刊：
影响因子：
--
通讯作者：
Roberts AC
中科院分区：
文献类型：
--
作者：
Walker SC;Mikheenko YP;Argyle LD;Robbins TW;Roberts AC
我们最近的研究表明，灵长类动物眼窝前额皮质（OFC）中的血清素有助于行为的灵活控制。5,7-二羟色胺诱导的5-羟色胺消耗对一系列逆转辨别任务的影响[j]。这种缺陷的特征是对先前奖励刺激的持续反应，这种缺陷类似于OFC固有神经元损伤后的缺陷[Nature， 380, 69-72]。这种作用是神经化学选择性的，因为6-羟多巴胺诱导的OFC的多巴胺能损伤没有作用[大脑皮层]。为了测试5 -羟色胺对眶额叶加工的一般性影响，特别是对灵活行为的影响，本研究调查了OFC的5 -羟色胺消耗对另一项依赖于OFC完整的任务的表现的影响，迂回任务[欧洲神经科学杂志，13,1797-1808]。这项任务的成功执行需要抑制动物的优势反应倾向，即沿着它的视线直接到达奖励。与假手术对照组相比，我们发现，在任务获取过程中，受损猴子在视线上直接到达可见奖励的障碍明显增加。这一发现为前额叶血清素在抑制控制过程中的作用提供了进一步的支持，特别是在对OFC功能障碍敏感的任务中。
We have recently shown that serotonin in the primate orbitofrontal cortex (OFC) contributes to the flexible control of behaviour. 5,7-dihydroxytryptamine-induced 5-HT depletions of OFC impair performance on a serial reversal discrimination task [ Science, 304, 878–880]. The deficit is characterized by perseverative responding to the previously rewarded stimulus, a deficit similar to that seen following lesions of the intrinsic neurones of the OFC [ Nature, 380, 69–72]. The effect is neurochemically selective as dopaminergic lesions of the OFC, induced by 6-hydroxydopamine, have no effect [ Cerebral Cortex]. In order to test for the generality of the effect of serotonin on orbitofrontal processing and, in particular, its effects on flexible behaviour, the present study investigated the effects of serotonin depletions of OFC on performance of another task dependent upon an intact OFC, the detour-reaching task [ European Journal of Neuroscience, 13, 1797–1808]. Successful performance of this task requires inhibition of the animal's prepotent response tendency to reach directly along its line of sight to the reward. Compared with sham-operated controls, we found that lesioned monkeys made significantly more barrier reaches directly along their line of sight to the visible reward during task acquisition. This finding provides further support for the role of prefrontal serotonin in inhibitory control processes specifically in tasks sensitive to OFC dysfunction.
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