Reinforcing effects of synthetic cathinones in rhesus monkeys: Dose-response and behavioral economic analyses.
Reinforcing effects of synthetic cathinones in rhesus monkeys: Dose-response and behavioral economic analyses.
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合成卡西酮在恒河猴中的强化作用：剂量反应和行为经济学分析。
DOI：
10.1016/j.pbb.2021.173112
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Kohut SJ
中科院分区：
文献类型：
--
作者：
de Moura FB;Sherwood A;Prisinzano TE;Paronis CA;Bergman J;Kohut SJ
具有精神兴奋剂和（或）致内陷作用的合成卡西酮（“浴盐”）作为可卡因或二亚甲基双氧苯丙胺等滥用药物的“法律的替代品引入后，其滥用成为一个公共卫生问题。在这项研究中，在非人类灵长类动物中进行了实验，以研究转运蛋白选择性的差异如何影响合成卡西酮的增强作用。恒河猴（N=5）进行训练，以响应静脉注射下的固定比例（FR）30，超时60秒的强化计划。选择的卡西酮（例如，在简单的FR时间表和行为经济学程序下，使用剂量反应分析将对多巴胺和5-羟色胺转运蛋白具有一系列药理学作用的MDPV、αPVP、MCAT和甲基酮（甲基酮）与可卡因和MDMA进行了比较，这些程序生成了每种药物两种剂量的需求曲线。结果显示，每例受试者均能自行给药一剂或多剂药物，除MDMA（21次注射/疗程）外，各药物的自行给药峰值水平相似（30-40次注射/疗程）。每种药物的峰值和峰值+1/2-log剂量的需求弹性没有显著差异，当对每种药物的两种剂量的数据取平均值时，出现了以下强化强度的等级顺序：可卡因> MCAT = MDPV =甲酮> αPVP = MDMA。这些结果表明，合成卡西酮的增强强度与其结合多巴胺或5-羟色胺转运体位点的选择性无关。
The abuse of synthetic cathinones (“bath salts”) with psychomotor stimulant and/or entactogenic properties emerged as a public health concern when they were introduced as “legal” alternatives to drugs of abuse such as cocaine or MDMA. In this study, experiments were conducted in nonhuman primates to examine how differences in transporter selectivity might impact the reinforcing effects of synthetic cathinones. Rhesus monkeys (N=5) were trained to respond for intravenous injections under a fixed-ratio (FR) 30, timeout 60-sec schedule of reinforcement. The reinforcing effects of selected cathinones (e.g., MDPV, αPVP, MCAT, and methylone) with a range of pharmacological effects at dopamine and serotonin transporters were compared to cocaine and MDMA using dose-response analysis under a simple FR schedule and behavioral economic procedures that generated demand curves for two doses of each drug. Results show that one or more doses of all drugs were readily self-administered in each subject and, excepting MDMA (21 injections/session), peak levels of self-administration were similar across drugs (between 30–40 injections/session). Demand elasticity for the peak and the peak + ½-log dose of each drug did not significantly differ, and when data for the two doses were averaged for each drug, the following rank-order of reinforcing strength emerged: cocaine > MCAT = MDPV = methylone > αPVP = MDMA. These results indicate that the reinforcing strength of synthetic cathinones are not related to their selectivity in binding dopamine or serotonin transporter sites .
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影响因子：
7.6
作者：
Gannon, Brenda M.;Galindo, Kayla I.;Collins, Gregory T.
通讯作者：
Collins, Gregory T.
影响因子：
6.1
作者：
German, Christopher L.;Fleckenstein, Annette E.;Hanson, Glen R.
通讯作者：
Hanson, Glen R.
影响因子：
7.6
作者：
Gannon, Brenda M.;Baumann, Michael H.;Collins, Gregory T.
通讯作者：
Collins, Gregory T.
影响因子：
3.4
作者：
Gannon BM;Mesmin MP;Sulima A;Rice KC;Collins GT
通讯作者：
Collins GT
DOI：
10.1124/jpet.116.239376
发表时间：
2017-04-01
影响因子：
3.5
作者：
Gannon, Brenda M.;Galindo, Kayla I.;Collins, Gregory T.
通讯作者：
Collins, Gregory T.