Associations between interhemispheric functional connectivity and the Automated Neuropsychological Assessment Metrics (ANAM) in civilian mild TBI.
Associations between interhemispheric functional connectivity and the Automated Neuropsychological Assessment Metrics (ANAM) in civilian mild TBI.
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DOI：
10.1007/s11682-014-9295-y
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发表时间：
2015-06
影响因子：
3.2
通讯作者：
Gullapalli, Rao P.
中科院分区：
文献类型：
--
作者：
Sours, Chandler;Rosenberg, Joseph;Kane, Robert;Roys, Steve;Zhuo, Jiachen;Shanmuganathan, Kathirkamanthan;Gullapalli, Rao P.
关键词：
本研究调查了具有高症状和低症状的平民轻度创伤性脑损伤 (mTBI) 参与者的认知缺陷和静息状态功能连接的改变。 41 名 mTBI 参与者在初始测试（受伤后 10 天以内）和一个月的随访期间完成了静息态 fMRI 扫描和自动神经心理学评估指标 (ANAM)。数据与 30 名健康对照受试者进行了比较。 ANAM 的结果表明，mTBI 参与者在代码替换延迟子测试 (p=0.032) 和加权吞吐量得分 (p=0.001) 方面的表现明显低于对照组。在 mTBI 患者中，高症状 mTBI 参与者在代码替换延迟 (p=0.017)、代码替换 (p=0.012)、重复简单反应时间 (p=0.031) 和加权吞吐量评分 (p=0.009) 方面的表现比低症状参与者差。影像学结果显示，在初次就诊期间，低症状 mTBI 参与者的侧顶叶内半球间功能连接 (IH-FC) 降低 (p=0.020)；然而，在随访过程中，与对照组相比，高症状 mTBI 参与者的背外侧前额皮质 (DLPFC) 内的 IH-FC 有所减少 (p=0.013)。随访期间 DLPFC 内 IH-FC 的减少与认知能力下降相关。总之，这些发现表明，与对照受试者和低症状 mTBI 参与者相比，rs-FC 减少可能导致高症状 mTBI 参与者出现微妙的认知缺陷。
This study investigates cognitive deficits and alterations in resting state functional connectivity in civilian mild traumatic brain injury (mTBI) participants with high and low symptoms. Forty-one mTBI participants completed a resting state fMRI scan and the Automated Neuropsychological Assessment Metrics (ANAM) during initial testing (<10 days of injury) and a one month follow up. Data were compared to 30 healthy control subjects. Results from the ANAM demonstrate that mTBI participants performed significantly worse than controls on the code substitution delayed subtest (p=0.032) and weighted throughput score (p=0.001). Among the mTBI patients, high symptom mTBI participants performed worse than those with low symptoms on the code substitution delayed (p=0.017), code substitution (p=0.012), repeated simple reaction time (p=0.031), and weighted throughput score (p=0.009). Imaging results reveal that during the initial visit, low symptom mTBI participants had reduced interhemispheric functional connectivity (IH-FC) within the lateral parietal lobe (p=0.020); however, during follow up, high symptom mTBI participants showed reduced IH-FC compared to the control group within the dorsolateral prefrontal cortex (DLPFC) (p=0.013). Reduced IH-FC within the DLPFC during the follow-up was associated with reduced cognitive performance. Together, these findings suggest that reduced rs-FC may contribute to the subtle cognitive deficits noted in high symptom mTBI participants compared to control subjects and low symptom mTBI participants.
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影响因子：
11
作者：
Maruishi, M.;Miyatani, M.;Muranaka, H.
通讯作者：
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影响因子：
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影响因子：
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