The influence of polyatomic primary ion chemistry on matrix effects in secondary ion mass spectrometry analysis.
The influence of polyatomic primary ion chemistry on matrix effects in secondary ion mass spectrometry analysis.
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多原子一次离子化学对二次离子质谱分析中基质效应的影响。
DOI：
10.1002/rcm.8265
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Alnajeebi AM
中科院分区：
文献类型：
--
作者：
Alnajeebi AM
合理应用质谱学成像技术来确定二维(2D)和三维(3D)化学分布，理想地提供了对多组分的均匀、高灵敏度和可靠的定量。由于分析物的化学成分和周围表面化学成分的不同，灵敏度不同，通常不符合这些标准。本文探讨了射束化学和样品化学对飞行时间二次离子质谱仪(TOF-SIMS)的影响。据作者所知，这是首次系统地研究了入射化学和样品环境对混合样品定量测定的综合影响。方法用飞行时间-飞行时间质谱仪测量了20 keV C60、Arn和(H2O)n团簇离子轰击(n= 2000或4000)下脂质和氨基酸混合物的二次离子产额。研究了在干样膜、海藻糖和水冰基质中的离子抑制/增强效应。结果发现，基质效应的程度和二次离子产率取决于一次离子束的化学和(对于C60，Arn)样品基质的性质。结论与C60和Arn相比，含水集束弹提高了TOF-SIMS测定所选分析物的灵敏度，降低了多组分样品和不同样品基质中信号抑制/增强的影响。一种可能的解释是，(H2O)4000弹丸在撞击纳米尺度的基质环境时启动，就所产生的电离效应而言，这与冷冻水合样品中的环境非常相似。含水的集束弹减少了分析物之间对质子的竞争和样品基质的影响。与非化学反应射束相比，这些化学反应射束具有更好的TOF-SIMS定量化学成像特性。
RationaleThe application of mass spectrometry imaging techniques to determine two‐ (2D) and three‐ (3D) dimensional chemical distribution ideally provides uniform, high sensitivity to multiple components and reliable quantification. These criteria are typically not met due to variations in sensitivity due to the chemistry of the analyte and surrounding surface chemistry. Here we explore the influence of projectile beam chemistry and sample chemistry in time‐of‐flight secondary ion mass spectrometry (TOF‐SIMS). To the authors' knowledge this is the first time the combined effects of projectile chemistry and sample environment on the quantitative determination of mixed samples have been systematically studied.MethodsSecondary ion yields of lipid and amino acid mixtures were measured under 20 keV C60, Arn, and (H2O)ncluster ion bombardment (n= 2000 or 4000) using TOF‐SIMS. Ion suppression/enhancement effects were studied in dry sample films and in trehalose and water ice matrices.ResultsThe extent of the matrix effects and the secondary ion yield were found to depend on the chemistry of the primary ion beam and (for C60, Arn) on the nature of the sample matrix. Under (H2O)nbombardment the sample matrix had negligible effect on the analysis.ConclusionsCompared with C60and Arn, water‐containing cluster projectiles enhanced the sensitivity of TOF‐SIMS determination of the chosen analytes and reduced the effect of signal suppression/enhancement in multicomponent samples and in different sample matrices. One possible explanation for this is that the (H2O)4000projectile initiates on impact a nanoscale matrix environment that is very similar to that in frozen‐hydrated samples in terms of the resulting ionisation effects. The competition between analytes for protons and the effect of the sample matrix are reduced with water‐containing cluster projectiles. These chemically reactive projectile beams have improved characteristics for quantitative chemical imaging by TOF‐SIMS compared with their non‐reactive counterparts.
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影响因子：
1.8
作者：
Jones, Emrys A.;Lockyer, Nicholas P.;Vickerman, John C.
通讯作者：
Vickerman, John C.
影响因子：
7.4
作者：
Delcorte, A.;Garrison, B. J.;Hamraoui, K.
通讯作者：
Hamraoui, K.
影响因子：
7.4
作者：
Rabbani, Sadia Sheraz Nee;Razo, Irma Berrueta;Vickerman, John C.
通讯作者：
Vickerman, John C.
影响因子：
2.1
作者：
Tian，Hua;Wucher，Andreas;Winograd，Nicholas
通讯作者：
Winograd，Nicholas
影响因子：
7.4
作者：
Adriaensen, L;Vangaever, F;Gijbels, R
通讯作者：
Gijbels, R