Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease.
Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer's disease.
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微生物群在神经炎症和突触功能障碍中的作用：聚焦阿尔茨海默病
DOI：
10.1186/s13024-022-00522-2
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发表时间：
2022-03-05
影响因子：
15.1
通讯作者：
Krantic S
中科院分区：
文献类型：
--
作者：
Bairamian D;Sha S;Rolhion N;Sokol H;Dorothée G;Lemere CA;Krantic S
肠道微生物群在健康和疾病中控制大脑功能的意义是一个新的、目前新兴的概念。越来越多的数据表明，肠道微生物群至少部分通过调节神经炎症来发挥作用。鉴于神经炎症变化与神经元活动之间的联系，肠道微生物群可能通过影响小胶质细胞（神经炎症的关键参与者）间接影响神经元功能。事实上，越来越多的证据表明，小胶质细胞和突触功能障碍之间的相互作用可能涉及微生物群等因素。除了微生物群对神经元活动的这些间接的小胶质细胞依赖性作用之外，最近已经认识到微生物群还可以通过刺激迷走神经直接影响神经元活动。微生物群对神经元活动的间接和直接影响的假定机制通过关注阿尔茨海默病来讨论，阿尔茨海默病是研究最多的神经退行性疾病之一，也是全球痴呆症的主要原因。更具体地说，微生物群介导的小胶质细胞改变的机制进行了讨论的背景下，外周和中央炎症串扰。接下来，我们强调微生物群在调节外周免疫体液介质中的作用及其对迷走神经刺激的影响。最后，我们讨论了微生物群扰动是否以及如何影响突触神经传递和下游认知功能障碍。越来越多的证据支持肠道微生物组在阿尔茨海默病发病机制中的作用，包括对突触功能障碍和神经炎症的影响，这有助于认知能力下降。基于微生物群调节的假定早期干预策略似乎对阿尔茨海默病有治疗前景，但仍需要进一步研究。
The implication of gut microbiota in the control of brain functions in health and disease is a novel, currently emerging concept. Accumulating data suggest that the gut microbiota exert its action at least in part by modulating neuroinflammation. Given the link between neuroinflammatory changes and neuronal activity, it is plausible that gut microbiota may affect neuronal functions indirectly by impacting microglia, a key player in neuroinflammation. Indeed, increasing evidence suggests that interplay between microglia and synaptic dysfunction may involve microbiota, among other factors. In addition to these indirect microglia-dependent actions of microbiota on neuronal activity, it has been recently recognized that microbiota could also affect neuronal activity directly by stimulation of the vagus nerve. The putative mechanisms of the indirect and direct impact of microbiota on neuronal activity are discussed by focusing on Alzheimer’s disease, one of the most studied neurodegenerative disorders and the prime cause of dementia worldwide. More specifically, the mechanisms of microbiota-mediated microglial alterations are discussed in the context of the peripheral and central inflammation cross-talk. Next, we highlight the role of microbiota in the regulation of humoral mediators of peripheral immunity and their impact on vagus nerve stimulation. Finally, we address whether and how microbiota perturbations could affect synaptic neurotransmission and downstream cognitive dysfunction. There is strong increasing evidence supporting a role for the gut microbiome in the pathogenesis of Alzheimer’s disease, including effects on synaptic dysfunction and neuroinflammation, which contribute to cognitive decline. Putative early intervention strategies based on microbiota modulation appear therapeutically promising for Alzheimer’s disease but still require further investigation.
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影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
De Vos W
影响因子：
7.7
作者：
Colombo AV;Sadler RK;Llovera G;Singh V;Roth S;Heindl S;Sebastian Monasor L;Verhoeven A;Peters F;Parhizkar S;Kamp F;Gomez de Aguero M;MacPherson AJ;Winkler E;Herms J;Benakis C;Dichgans M;Steiner H;Giera M;Haass C;Tahirovic S;Liesz A
通讯作者：
Liesz A
影响因子：
5.1
作者：
Bonfili L;Cecarini V;Cuccioloni M;Angeletti M;Berardi S;Scarpona S;Rossi G;Eleuteri AM
通讯作者：
Eleuteri AM
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
4.8
作者：
Akbari E;Asemi Z;Daneshvar Kakhaki R;Bahmani F;Kouchaki E;Tamtaji OR;Hamidi GA;Salami M
通讯作者：
Salami M