Clinical usefulness of a novel high-sensitivity hepatitis B core-related antigen assay to determine the initiation of treatment for HBV reactivation
Clinical usefulness of a novel high-sensitivity hepatitis B core-related antigen assay to determine the initiation of treatment for HBV reactivation
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新型高灵敏度乙型肝炎核心相关抗原测定在确定乙型肝炎病毒再激活治疗开始方面的临床用途
DOI：
10.1007/s00535-022-01872-w
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发表时间：
2022
影响因子：
6.3
通讯作者：
Tanaka Yasuhito
中科院分区：
文献类型：
--
作者：
Suzuki Takanori;Inoue Takako;Matsuura Kentaro;Kusumoto Shigeru;Hagiwara Shinya;Ogawa Shintaro;Yagi Shintaro;Kaneko Atsushi;Fujiwara Kei;Watanabe Takehisa;Aoyagi Katsumi;Urata Yukitomo;Tamori Akihiro;Kataoka Hiromi;Tanaka Yasuhito
背景一种全自动、高灵敏度的新型B型肝炎核心相关抗原检测方法（iTACT-HBcrAg）正在发展中。本研究的目的是评估测量HBcrAg的有效性，使用该检测，诊断HBV再激活在多中心设置，与超高灵敏度HBsAg（iTACT-HBsAg）和HBV DNA检测相比，MethodsForty 4例HBV再激活患者从2008年至2020年在四家医院参加。回顾性评估了患者的系列血清标本的HBcrAg水平（检测下限; 2.0 log U/mL）和HBsAg水平（检测下限; 0.0005 IU/mL），并将其与HBV DNA水平进行比较。HBV再激活定义为血清HBV DNA的检测，包括不可定量的detect.ResultsAt HBV再激活和/或其后，HBV DNA水平定量（≥ 1.3 log IU/mL）在27例患者的血清中，和低于定量水平（< 1.3 log IU/mL）在17例患者的血清中。在27例HBV再激活患者中，iTACT-HBcrAg和iTACT-HBsAg分别有26例和24例（96.3%和88.9%）阳性。27例患者中有15例在HBV DNA可定量之前，iTACT-HBcrAg可检出HBcrAg。在11例HBV再激活和检测不到HBcrAg的iTACT-HBcrAg在HBV再激活和/或其后，10个有不可定量的HBV DNA，没有开发HBV再激活相关hepatis.ConclusionsThe iTACT-HBcrAg检测是有用的监测HBV再激活，以确定治疗的开始与核苷（酸）类似物。
BackgroundsA fully automated, novel, high-sensitivity hepatitis B core-related antigen assay (iTACT-HBcrAg) has been developing. The purpose of this study is to evaluate the efficacy of measuring HBcrAg, using that assay, to diagnose HBV reactivation in a multi-center setting, compared with ultra-high-sensitivity HBsAg (iTACT-HBsAg) and HBV DNA assays.MethodsForty-four patients with HBV reactivation from 2008 to 2020 were enrolled in four hospitals. Serial serum specimens from the patients were assessed retrospectively for their HBcrAg levels by iTACT-HBcrAg (lower limit of detection; 2.0 log U/mL) and HBsAg levels by iTACT-HBsAg (lower limit of detection; 0.0005 IU/mL); these were compared to the HBV DNA levels. HBV reactivation was defined as detection of serum HBV DNA, including unquantifiable detection.ResultsAt HBV reactivation and/or thereafter, HBV DNA levels were quantified (≥ 1.3 log IU/mL) in the sera of 27 patients, and were below the level of quantification (< 1.3 log IU/mL) in the sera of 17 patients. Of the 27 patients with HBV reactivation and whose serum HBV DNA was quantified, the sera of 26 and 24 patients (96.3% and 88.9%) were positive by iTACT-HBcrAg and iTACT-HBsAg, respectively. HBcrAg was detectable by iTACT-HBcrAg before HBV DNA was quantifiable in 15 of the 27 patients. Of the 11 patients with HBV reactivation and undetectable HBcrAg by iTACT-HBcrAg at HBV reactivation and/or thereafter, 10 had unquantifiable HBV DNA and none developed HBV reactivation-related hepatitis.ConclusionsThe iTACT-HBcrAg assay is useful for monitoring HBV reactivation to determine the initiation of treatment with nucleos(t)ide analogues.
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DOI：
10.1111/j.1440-1746.2005.04087.x
发表时间：
2005-11-01
影响因子：
4.1
作者：
Rokuhara, A;Sun, XH;Kiyosawa, K
通讯作者：
Kiyosawa, K
乙型肝炎核心相关抗原测定可识别高病毒载量患者：个体参与者数据的系统回顾和荟萃分析。
影响因子：
12.6
作者：
Kyoko Yoshida;A. Desbiolles;Sarah F Feldman;S. Ahn;E. K. Alidjinou;M. Atsukawa;L. Bocket;M. Brunetto;M. Buti;I. Carey;G. P. Caviglia;E. Chen;M. Cornberg;M. Enomoto;M. Honda;Christoph Höner zu Siederdissen;M. Ishigami;H. Janssen;B. Maasoumy;Takeshi Matsui;A. Matsumoto;S. Nishiguchi;M. Riveiro‐Barciela;A. Takaki;P. Tangkijvanich;H. Toyoda;M. J. V. van Campenhout;Bo Wang;Lai Wei;Hwai I. Yang;Y. Yano;H. Yatsuhashi;M. Yuen;E. Tanaka;M. Lemoine;Yasuhito Tanaka;Y. Shimakawa
通讯作者：
Y. Shimakawa
新开发的高灵敏乙型肝炎表面抗原 (HBsAg) 检测在监测乙型肝炎再激活方面的临床实用性
DOI：
10.2957/kanzo.60.237
发表时间：
2019
期刊：
Kanzo
影响因子：
--
作者：
K. Oone;Takako Inoue;S. Kusumoto;Tomoyuki Ohike;Takaaki Goto;Shigeru Sato;Yasuhito Tanaka
通讯作者：
Yasuhito Tanaka
影响因子：
25.7
作者：
Kusumoto, Shigeru;Tanaka, Yasuhito;Mizokami, Masashi
通讯作者：
Mizokami, Masashi
DOI：
10.1002/hep.29800
发表时间：
2018-04
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Terrault NA;Lok ASF;McMahon BJ;Chang KM;Hwang JP;Jonas MM;Brown RS Jr;Bzowej NH;Wong JB
通讯作者：
Wong JB