Visual-auditory spatial processing in auditory cortical neurons.
Visual-auditory spatial processing in auditory cortical neurons.
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DOI：
10.1016/j.brainres.2008.02.087
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发表时间：
2008-11-25
期刊：
影响因子：
2.9
通讯作者：
King, Andrew J.
中科院分区：
文献类型：
--
作者：
Bizley, Jennifer K.;King, Andrew J.
关键词：
现在已经在不同物种的听觉皮层中描述了对视觉刺激做出反应的神经元，但它们的功能很大程度上未知。在这里，我们研究了雪貂 5 个不同的初级和非初级听觉皮层区域中记录的神经元的听觉和视觉空间敏感性。我们通过测量对一系列方位角位置上呈现的刺激的反应并计算神经反应与引起它们的刺激的位置之间的互信息（MI）来量化神经元的空间调谐。针对单感觉视觉、单感觉听觉以及空间和时间上一致的听觉-视觉刺激计算空间调谐的 MI 估计。大多数视觉响应单元传达有关光源位置的重要信息，而在相应的空间区域上，声音响应单元通常传送较少的有关声源位置的信息。视觉、听觉和双感觉刺激的空间敏感性在前背侧区域最高，听觉区域先前被证明受外纹视觉皮层区域的支配，被认为主要与空间处理有关，而后假侧裂区域和后上侧裂区域的主要视觉输入来自似乎是“什么”处理流一部分的皮层区域，传达的有关刺激位置的信息较少。在一些神经元中，视觉和听觉刺激的配对导致相对于最有效的单感觉刺激而言可用的空间信息增加，而在较小的亚群中，组合刺激降低了空间MI。这些数据表明，听觉皮层的视觉输入可以增强多感官线索存在下的空间处理，因此可能是视觉对听觉定位的影响的基础。
Neurons responsive to visual stimulation have now been described in the auditory cortex of various species, but their functions are largely unknown. Here we investigate the auditory and visual spatial sensitivity of neurons recorded in 5 different primary and non-primary auditory cortical areas of the ferret. We quantified the spatial tuning of neurons by measuring the responses to stimuli presented across a range of azimuthal positions and calculating the mutual information (MI) between the neural responses and the location of the stimuli that elicited them. MI estimates of spatial tuning were calculated for unisensory visual, unisensory auditory and for spatially and temporally coincident auditory-visual stimulation. The majority of visually responsive units conveyed significant information about light-source location, whereas, over a corresponding region of space, acoustically responsive units generally transmitted less information about sound-source location. Spatial sensitivity for visual, auditory and bisensory stimulation was highest in the anterior dorsal field, the auditory area previously shown to be innervated by a region of extrastriate visual cortex thought to be concerned primarily with spatial processing, whereas the posterior pseudosylvian field and posterior suprasylvian field, whose principal visual input arises from cortical areas that appear to be part of the ‘what’ processing stream, conveyed less information about stimulus location. In some neurons, pairing visual and auditory stimuli led to an increase in the spatial information available relative to the most effective unisensory stimulus, whereas, in a smaller subpopulation, combined stimulation decreased the spatial MI. These data suggest that visual inputs to auditory cortex can enhance spatial processing in the presence of multisensory cues and could therefore potentially underlie visual influences on auditory localization.
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影响因子：
2.5
作者：
Foxe, JJ;Wylie, GR;Murray, MM
通讯作者：
Murray, MM
影响因子：
3.7
作者：
Molholm, S;Ritter, W;Foxe, JJ
通讯作者：
Foxe, JJ
DOI：
10.1093/cercor/bhl128
发表时间：
2007-09
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Bizley JK;Nodal FR;Bajo VM;Nelken I;King AJ
通讯作者：
King AJ
影响因子：
56.9
作者：
MEREDITH, MA;STEIN, BE
通讯作者：
STEIN, BE
DOI：
10.1016/s0926-6410(02)00066-6
发表时间：
2002-06-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Molholm, S;Ritter, W;Foxe, JJ
通讯作者：
Foxe, JJ