13C-phenylalanine breath test detects altered phenylalanine kinetics in schizophrenia patients.
13C-phenylalanine breath test detects altered phenylalanine kinetics in schizophrenia patients.
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DOI：
10.1038/tp.2012.48
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发表时间：
2012-05-22
影响因子：
6.8
通讯作者：
Kunugi H
中科院分区：
文献类型：
--
作者：
Teraishi T;Ozeki Y;Hori H;Sasayama D;Chiba S;Yamamoto N;Tanaka H;Iijima Y;Matsuo J;Kawamoto Y;Kinoshita Y;Hattori K;Ota M;Kajiwara M;Terada S;Higuchi T;Kunugi H
苯丙氨酸是合成包括多巴胺在内的儿茶酚胺所需的必需氨基酸。据报道，精神分裂症患者血液和脑脊液中苯丙氨酸及其代谢产物水平发生变化。本研究首次采用L-[1- 13 C]苯丙氨酸呼气试验（13 C-PBT）检测精神分裂症患者苯丙氨酸代谢动力学是否改变。受试者为20例长期服药的精神分裂症患者（DSM-IV）和相同数量的年龄和性别匹配的对照组。口服13 C-苯丙氨酸（99原子% 13 C; 100 mg），监测呼吸13 CO2/12 CO2比值120 min。在大鼠中检查了抗精神病药物（利培酮（RPD）或氟哌啶醇（HPD）治疗21天）对13 C-PBT的可能影响。体重（BW）、年龄和诊断状态是Δ 13 CO2时程曲线下面积（‰）和120 min累积恢复率（CRR）的显著预测因素。对年龄和BW控制的协方差进行的重复测量分析显示，患者和对照组之间CRR随时间变化的模式不同，并且在120 min试验期间的所有采样时间点，患者的Δ 13 CO2均低于对照组，两组之间存在总体显著差异。长期给予RPD或HPD对大鼠的13 C-PBT指数无显著影响。我们的研究结果表明，13 C-PBT是一种新的实验室测试，可以检测慢性精神分裂症患者的苯丙氨酸动力学改变。动物实验表明，观察到的变化不太可能归因于抗精神病药物。
Phenylalanine is an essential amino acid required for the synthesis of catecholamines including dopamine. Altered levels of phenylalanine and its metabolites in blood and cerebrospinal fluid have been reported in schizophrenia patients. This study attempted to examine for the first time whether phenylalanine kinetics is altered in schizophrenia using L-[1-13C]phenylalanine breath test (13C-PBT). The subjects were 20 chronically medicated schizophrenia patients (DSM-IV) and the same number of age- and sex-matched controls. 13C-phenylalanine (99 atom% 13C; 100 mg) was administered orally and the breath 13CO2 /12CO2 ratio was monitored for 120 min. The possible effect of antipsychotic medication (risperidone (RPD) or haloperidol (HPD) treatment for 21 days) on 13C-PBT was examined in rats. Body weight (BW), age and diagnostic status were significant predictors of the area under the curve of the time course of Δ13CO2 (‰) and the cumulative recovery rate (CRR) at 120 min. A repeated measures analysis of covariance controlled for age and BW revealed that the patterns of CRR change over time differed between the patients and controls and that Δ13CO2 was lower in the patients than in the controls at all sampling time points during the 120 min test, with an overall significant difference between the two groups. Chronic administration of RPD or HPD had no significant effect on 13C-PBT indices in rats. Our results suggest that 13C-PBT is a novel laboratory test that can detect altered phenylalanine kinetics in chronic schizophrenia patients. Animal experiments suggest that the observed changes are unlikely to be attributable to antipsychotic medication.
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影响因子：
1.7
作者：
Ishii, T;Furube, M;Kajiwara, M
通讯作者：
Kajiwara, M
影响因子：
4.1
作者：
Laruelle, M;Abi-Dargham, P
通讯作者：
Abi-Dargham, P
影响因子：
10.6
作者：
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BOULTON, AA
DOI：
10.1017/s1461145799001522
发表时间：
1999-09-01
影响因子：
4.8
作者：
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通讯作者：
Awouters, FHL
影响因子：
3.6
作者：
LASCHINSKI, G;KITTNER, B;BRAUTIGAM, M
通讯作者：
BRAUTIGAM, M