LILRB receptor-mediated regulation of myeloid cell maturation and function.
LILRB receptor-mediated regulation of myeloid cell maturation and function.
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DOI：
10.1007/s00262-017-2023-x
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Chen SH
中科院分区：
文献类型：
--
作者：
van der Touw W;Chen HM;Pan PY;Chen SH
白细胞免疫球蛋白样受体(LILR)家族包括一组在人髓系和淋巴细胞群体中表达的成对免疫调节受体。LILR亚家族A(LILRA)有6个成员与膜适配器结合，通过免疫受体酪氨酸激活基序(ITAM)传递信号，而LILR亚家族B(LILRB)成员通过多个胞浆免疫受体酪氨酸抑制基序(ITIM)传递信号。一些LILR家族成员的配基特异性已被详细研究，但对该受体家族在人类髓系细胞中的免疫调节方面的新视角一直受到限制。LILRB受体和小鼠成对免疫球蛋白样受体B(PirB)已被证明对包括肥大细胞、中性粒细胞、树突状细胞和B细胞在内的髓系细胞的成熟途径具有负向调节作用。我们的实验室在小鼠模型中进一步证明了PirB调控髓系来源的抑制细胞的功能发育和肿瘤允许微环境的形成。基于对文献的观察和我们自己的研究，我们的实验室专注于LILRs如何调节人类髓系细胞的免疫稳态，以及这些途径如何在疾病状态下成为靶点。例如，在肿瘤微环境中，这一途径的完整性允许髓系表型抑制抗肿瘤获得性免疫。这篇综述介绍了支持LILRs作为髓系细胞调节器的作用的证据，以及正在进行的了解围绕该家族的功能免疫学的努力。
The leukocyte immunoglobulin-like receptor (LILR) family comprises a set of paired immunomodulatory receptors expressed among human myeloid and lymphocyte cell populations. While six members of LILR subfamily A (LILRA) associate with membrane adaptors to signal via immunoreceptor tyrosine-based activating motifs (ITAM), LILR subfamily B (LILRB) members signal via multiple cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIM). Ligand specificity of some LILR family members has been studied in detail, but new perspective into the immunoregulatory aspects of this receptor family in human myeloid cells has been limited. LILRB receptors and the murine ortholog, paired immunoglobulin-like receptor B (PIRB), have been shown to negatively regulate maturation pathways in myeloid cells including mast cells, neutrophils, dendritic cells, as well as B cells. Our laboratory further demonstrated in mouse models that PIRB regulated functional development of myeloid-derived suppressor cell and the formation of a tumor-permissive microenvironment. Based on observations from the literature and our own studies, our laboratory is focusing on how LILRs modulate immune homeostasis of human myeloid cells and how these pathways may be targeted in disease states. Integrity of this pathway in tumor microenvironments, for example, permits a myeloid phenotype that suppresses antitumor adaptive immunity. This review presents the evidence supporting a role of LILRs as myeloid cell regulators and ongoing efforts to understand the functional immunology surrounding this family.
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影响因子：
5.2
作者：
Kuroki K;Furukawa A;Maenaka K
通讯作者：
Maenaka K
人类巨噬细胞的高分辨率转录组。
影响因子：
3.7
作者：
Beyer M;Mallmann MR;Xue J;Staratschek-Jox A;Vorholt D;Krebs W;Sommer D;Sander J;Mertens C;Nino-Castro A;Schmidt SV;Schultze JL
通讯作者：
Schultze JL
DOI：
10.1126/science.1242077
发表时间：
2013-09-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kim T;Vidal GS;Djurisic M;William CM;Birnbaum ME;Garcia KC;Hyman BT;Shatz CJ
通讯作者：
Shatz CJ
影响因子：
32.4
作者：
Anfossi, Nicolas;Andre, Pascale;Vivier, Eric
通讯作者：
Vivier, Eric
影响因子：
2.7
作者：
Davidson, Chelsea L.;Li, Nicholas L.;Burshtyn, Deborah N.
通讯作者：
Burshtyn, Deborah N.