Adaptation and Evolution of Pathogens in the Cystic Fibrosis Lung.
Adaptation and Evolution of Pathogens in the Cystic Fibrosis Lung.
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DOI：
10.1093/jpids/piac073
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发表时间：
2022-09-07
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
--
作者：
与急性呼吸道感染相反，以囊性纤维化（CF）为特征的肺部持续性细菌感染为细菌进化和适应提供了充足的时间。适应过程记录在感染细菌基因组中随时间积累的突变中。这些突变中的一些导致明显的表型差异，例如抗生素抗性或铜绿假单胞菌的众所周知的粘液样表型。其他突变可能同样重要，但更难检测，例如突变率增加，细胞表面变化以及代谢和营养获取的变化。值得注意的是，许多适应性变化在不同的患者中一次又一次地发生，这表明细菌正在适应CF呼吸道中的特定挑战。这种平行进化甚至延伸到不同的细菌物种。本文综述了已知在长期CF感染中发生变化的细菌系统，特别强调跨物种比较。考虑到适应可能会影响CF的健康，以及可能的进化机制，导致重复的平行适应。
As opposed to acute respiratory infections, the persistent bacterial infections of the lung that characterize cystic fibrosis (CF) provide ample time for bacteria to evolve and adapt. The process of adaptation is recorded in mutations that accumulate over time in the genomes of the infecting bacteria. Some of these mutations lead to obvious phenotypic differences such as antibiotic resistance or the well-known mucoid phenotype of Pseudomonas aeruginosa. Other mutations may be just as important but harder to detect such as increased mutation rates, cell surface changes, and shifts in metabolism and nutrient acquisition. Remarkably, many of the adaptations occur again and again in different patients, signaling that bacteria are adapting to solve specific challenges in the CF respiratory tract. This parallel evolution even extends across distinct bacterial species. This review addresses the bacterial systems that are known to change in long-term CF infections with a special emphasis on cross-species comparisons. Consideration is given to how adaptation may impact health in CF, and the possible evolutionary mechanisms that lead to the repeated parallel adaptations.
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影响因子：
5.8
作者：
Chua SL;Ding Y;Liu Y;Cai Z;Zhou J;Swarup S;Drautz-Moses DI;Schuster SC;Kjelleberg S;Givskov M;Yang L
通讯作者：
Yang L
影响因子：
3.1
作者：
Chung, JW;Altman, E;Speert, DP
通讯作者：
Speert, DP
影响因子：
3.7
作者：
Cigana C;Curcurù L;Leone MR;Ieranò T;Lorè NI;Bianconi I;Silipo A;Cozzolino F;Lanzetta R;Molinaro A;Bernardini ML;Bragonzi A
通讯作者：
Bragonzi A
影响因子：
9.4
作者：
BARTH, AL;PITT, TL
通讯作者：
PITT, TL
影响因子：
3.2
作者：
Boucher, JC;MartinezSalazar, J;Deretic, V
通讯作者：
Deretic, V