Maternal occupational exposure to organic solvents during early pregnancy and risks of neural tube defects and orofacial clefts.
Maternal occupational exposure to organic solvents during early pregnancy and risks of neural tube defects and orofacial clefts.
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DOI：
10.1136/oemed-2011-100245
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发表时间：
2012-07
影响因子：
4.9
通讯作者：
National Birth Defects Prevention Study
中科院分区：
文献类型：
--
作者：
Desrosiers TA;Lawson CC;Meyer RE;Richardson DB;Daniels JL;Waters MA;van Wijngaarden E;Langlois PH;Romitti PA;Correa A;Olshan A;National Birth Defects Prevention Study
尽管毒理学实验证明有机溶剂在动物模型中具有致畸性，但流行病学研究报告的结果不一致。利用基于人口的国家出生缺陷预防研究的数据，我们研究了孕早期母亲职业接触芳香族溶剂、氯化溶剂和斯托达德溶剂与神经管缺陷 (NTD) 和口面裂 (OFC) 之间的关系。 8 个州的出生缺陷监测登记处发现了 1997 年至 2002 年间分娩的 NTD（无脑畸形、脊柱裂和脑膨出）和 OFC（唇裂±腭裂和单纯腭裂）病例；使用出生证明或医院记录选择非畸形对照婴儿。母亲的溶剂暴露量是通过工业卫生学家对自我报告的职业史的审查并结合文献得出的暴露数据库来估计的。使用多变量逻辑回归估计溶剂类别与每个出生缺陷组和组成表型之间关联的比值比 (OR) 和 95% 置信区间 (CI)，并调整母亲年龄、种族/民族、教育程度、孕前体重指数、叶酸补充剂使用和吸烟情况。 NTD 病例 (n=511)、OFC 病例 (n=1163) 和对照组 (n=2977) 的母亲接触任何溶剂的比例分别为 13.1%、9.6% 和 8.2%。接触氯化溶剂与 NTD 发生率增加相关（OR=1.96；CI=1.34，2.87），尤其是脊柱裂（OR=2.26；CI=1.44，3.53）。在这些数据中，没有溶剂类别与 OFC 密切相关。我们的研究结果表明，母亲在怀孕早期职业性接触氯化溶剂与后代 NTD 患病率呈正相关。
Though toxicological experiments demonstrate the teratogenicity of organic solvents in animal models, epidemiologic studies have reported inconsistent results. Using data from the population-based National Birth Defects Prevention Study, we examined the relation between maternal occupational exposure to aromatic solvents, chlorinated solvents and Stoddard solvent during early pregnancy and neural tube defects (NTDs) and orofacial clefts (OFCs). Cases of NTDs (anencephaly, spina bifida and encephalocele) and OFCs (cleft lip ± cleft palate and cleft palate alone) delivered between 1997 and 2002 were identified by birth defect surveillance registries in 8 states; non-malformed control infants were selected using birth certificates or hospital records. Maternal solvent exposure was estimated by industrial hygienist review of self-reported occupational histories in combination with a literature-derived exposure database. Odds ratios (OR) and 95% confidence intervals (CI) for the association between solvent class and each birth defect group and component phenotype were estimated using multivariable logistic regression, adjusting for maternal age, race/ethnicity, education, pre-pregnancy body mass index, folic acid supplement use and smoking. The prevalence of exposure to any solvent among mothers of NTD cases (n=511), OFC cases (n=1163) and controls (n=2977) was 13.1%, 9.6% and 8.2%, respectively. Exposure to chlorinated solvents was associated with increased odds of NTDs (OR=1.96; CI=1.34, 2.87), especially spina bifida (OR=2.26; CI=1.44, 3.53). No solvent class was strongly associated with OFCs in these data. Our findings suggest that maternal occupational exposure to chlorinated solvents during early pregnancy is positively associated with the prevalence of NTDs in offspring.
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影响因子：
3.3
作者：
Laumon, B;Martin, JL;Robert, E
通讯作者：
Robert, E
DOI：
10.1002/ajmg.1320440210
发表时间：
1992-09-15
期刊：
AMERICAN JOURNAL OF MEDICAL GENETICS
影响因子：
--
作者：
KOTCH, LE;SULIK, KK
通讯作者：
SULIK, KK
影响因子：
6.3
作者：
CORDIER, S;HA, MC;GOUJARD, J
通讯作者：
GOUJARD, J
DOI：
10.1002/tera.1420460110
发表时间：
1992-07-01
期刊：
TERATOLOGY
影响因子：
--
作者：
KHOURY, MJ;JAMES, LM;ERICKSON, JD
通讯作者：
ERICKSON, JD
DOI：
10.1002/bdra.20671
发表时间：
2010-08-01
影响因子：
--
作者：
Lupo, Philip J.;Symanski, Elaine;Mitchel, Laura E.
通讯作者：
Mitchel, Laura E.