Inflammatory Bowel Disease and Sarcopenia: Its Mechanism and Clinical Importance.
Inflammatory Bowel Disease and Sarcopenia: Its Mechanism and Clinical Importance.
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炎症性肠病与肌肉减少症的发病机制及临床意义。
DOI：
10.3390/jcm10184214
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发表时间：
2021-09-17
影响因子：
3.9
通讯作者：
Higuchi K
中科院分区：
文献类型：
--
作者：
Nishikawa H;Nakamura S;Miyazaki T;Kakimoto K;Fukunishi S;Asai A;Nishiguchi S;Higuchi K
营养不良是肌肉萎缩和肌肉功能障碍的主要原因，也就是所谓的骨质疏松症。营养不良在炎症性肠病(IBD)患者中很常见。IBD包括溃疡性结肠炎(UC)和克罗恩病(CD)。最近，IBD患者的数量一直在增加。与UC相比，CD的营养不良更为严重，可能是由于CD影响营养吸收的主要部位、广泛的粘膜病变、瘘管、切除后短肠综合征或胃肠道梗阻。最近的一项荟萃分析显示，IBD患者中石膏量减少的发生率很高，因此石膏量减少是IBD的一个非常重要的问题。虽然IBD在年轻患者中更为常见，但骨质疏松症可以通过多种机制发展，包括营养不良、慢性炎症、脂肪组织炎症状态增加、维生素缺乏和肌肉-肠轴失衡。此外，骨量减少对IBD患者术后并发症和住院时间有负面影响。除了IBD患者的临床缓解和内窥镜黏膜愈合外，适当的干预措施可能也很重要。因此，IBD患者的骨质疏松症将受到更多关注。在这篇综述中，我们在现有证据的基础上，概述IBD和石棺减少症。
Malnutrition is a major contributor to muscle loss and muscle dysfunction, known as sarcopenia. Malnutrition is common in patients with inflammatory bowel disease (IBD). IBD includes ulcerative colitis (UC) and Crohn’s disease (CD). The number of patients with IBD has recently been increasing. More severe malnutrition is often seen in CD compared to UC, probably due to CD affecting the main site of nutrient absorption, extensive mucosal lesions, fistulas, short bowel syndrome after resection, or obstruction of the gastrointestinal tract. A recent meta-analysis showed the high prevalence of sarcopenia in patients with IBD, and thus sarcopenia is a very important problem for IBD. Although IBD is more common in younger patients, sarcopenia can develop through a variety of mechanisms, including malnutrition, chronic inflammation, increased inflammatory status in adipose tissue, vitamin deficiency, and imbalance of the muscle–gut axis. In addition, sarcopenia has a negative impact on postoperative complications and hospital stay in patients with IBD. Appropriate intervention for sarcopenia may be important, in addition to clinical remission and endoscopic mucosal healing in patients with IBD. Much more attention will thus be paid to sarcopenia in patients with IBD. In this review, we outline IBD and sarcopenia, based on the current evidence.
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影响因子：
2.6
作者：
Celentano V;Kamil-Mustafa L;Beable R;Ball C;Flashman KG;Jennings Z;O' Leary DP;Higginson A;Luxton S
通讯作者：
Luxton S
影响因子：
3.7
作者：
Bamba S;Sasaki M;Takaoka A;Takahashi K;Imaeda H;Nishida A;Inatomi O;Sugimoto M;Andoh A
通讯作者：
Andoh A
DOI：
10.1097/00005176-199802000-00002
发表时间：
1998-02-01
影响因子：
2.9
作者：
Bousvaros, A;Zurakowski, D;Leichtner, AM
通讯作者：
Leichtner, AM
影响因子：
8
作者：
Cushing, Kelly C.;Kordbacheh, Hamed;Ananthakrishnan, Ashwin N.
通讯作者：
Ananthakrishnan, Ashwin N.
影响因子：
6.3
作者：
Cederholm, T.;Barazzoni, R.;Singer, P.
通讯作者：
Singer, P.