Association of Lp-PLA2 Mass and Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.
Association of Lp-PLA2 Mass and Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.
复制标题
DOI：
10.1371/journal.pone.0130473
复制
发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Zhu D
中科院分区：
文献类型：
--
作者：
Wang Y;Zhang J;Qian Y;Tang X;Ling H;Chen K;Gao P;Zhu D
颅内动脉狭窄（ICAS）是亚洲人缺血性中风的常见原因，而白人往往有更多的颅外病变。脂蛋白相关磷脂酶A2 （Lp-PLA2）已被大量研究证实与缺血性脑卒中有关。然而，关于Lp-PLA2与无症状ICAS或颅外动脉狭窄（ECAS）关系的研究较少。因此，我们试图探讨中国人群无卒中高血压患者Lp-PLA2与ICAS、ECAS及并发狭窄的关系。所有受试者通过覆盖全脑至主动脉弓水平的计算机断层血管造影（CTA）评估ICAS和ECAS的存在和严重程度。酶联免疫法测定Lp-PLA2质量。通过多因素logistic回归分析Lp-PLA2与血管狭窄的相关性。在414名参与者中，163名（39.4%）没有ICAS或ECAS， 63名（15.2%）仅有ECAS， 111名（26.8%）仅有ICAS， 77名（18.6%）合并颅外狭窄。Lp-PLA2质量与孤立的ICAS （OR: 2.3; 95% CI: 1.14-4.64）和并发狭窄（OR: 3.93; 95% CI: 1.62-9.51）显著相关，但与孤立的ECAS无关（OR: 1.54; 95% CI: 0.68-3.48）。无论ECAS如何，Lp-PLA2质量也与中度至重度ICAS相关。Lp-PLA2肿块越大，ICAS越严重，颅内动脉病变越多。本研究揭示了中国人群无卒中高血压患者Lp-PLA2质量与ICAS的关系。需要进一步的长期队列研究来阐明Lp-PLA2对无症状ICAS的具体作用。
Intracranial arterial stenosis (ICAS) is a common cause of ischemic stroke in Asians, whereas whites tend to have more extracranial lesions. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been associated with ischemic stroke by a large amount of work. However, there are few studies focusing on the relationship of Lp-PLA2 and asymptomatic ICAS or extracranial arterial stenosis (ECAS). Wehereby sought to explore the relationship of Lp-PLA2 and ICAS, ECAS and concurrent stenosis in stroke-free hypertensive patients in Chinese population. All the subjects were evaluated for the presence and severity of ICAS and ECAS through computerized tomographic angiography (CTA) covered the whole brain down to the level of aortic arch. Lp-PLA2 mass was measured by enzyme linked immunoassay. The association of Lp-PLA2 and vascular stenosis was analyzed through multivariate logistic regression. Among 414 participants, 163 (39.4%) had no ICAS or ECAS, 63 (15.2%) had ECAS only, 111 (26.8%) had ICAS only and 77 (18.6%) had concurrent extraintracranial stenosis. Lp-PLA2 mass was significantly associated with isolated ICAS (OR: 2.3; 95% CI: 1.14-4.64), and concurrent stenosis (OR: 3.93; 95% CI: 1.62-9.51), but was not related to isolated ECAS (OR: 1.54; 95% CI: 0.68-3.48). Lp-PLA2 mass was also associated with moderate to severe ICAS no matter how was the ECAS. Moreover, patients with higher Lp-PLA2 mass showed more sever ICAS and had more intracranial arterial lesions. This study revealed the association of Lp-PLA2 mass with ICAS in stroke-free hypertensive patients in Chinese population. The further long-term cohort study was warranted to elucidate the concrete effect of Lp-PLA2 on the asymptomatic ICAS.
登录
查看更多内容
影响因子：
158.5
作者：
Packard, CJ;O'Reilly, DSJ;Lowe, GDO
通讯作者：
Lowe, GDO
影响因子：
5.3
作者：
Honda, HM;Hsiai, T;Demer, LL
通讯作者：
Demer, LL
影响因子：
8.3
作者：
Anderson, GB;Ashforth, R;Findlay, JM
通讯作者：
Findlay, JM
DOI：
10.1161/01.atv.0000201289.83256.cf
发表时间：
2006-03-01
影响因子：
8.7
作者：
Kardys, I;Oei, HHS;Witteman, JCM
通讯作者：
Witteman, JCM
影响因子：
8.3
作者：
Hsia, DC;Moscoe, LM;Krushat, M
通讯作者：
Krushat, M