Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor.
Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor.
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DOI：
10.3390/metabo13020251
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发表时间：
2023-02-09
期刊：
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
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作者：
心肌梗塞（MI）是一种由于冠状动脉阻塞而发生的心血管疾病。随后，心肌接受较低的氧气供应，导致心肌死亡。心肌梗死的病因与各种环境、职业和遗传因素有关。对心肌梗死相关基因的多态性进行了多种研究。以往的研究表明，亚甲基四氢叶酸还原酶（MTHFR）基因的不同变异通过改变叶酸和同型半胱氨酸的代谢参与心肌梗死的发生。然而，MTHFR C677T （rs1801133）基因多态性及其与糖尿病（DM）患者心肌梗死的相关性仍需进一步研究。本研究招募了300名参与者，他们被分为三组，即对照组、心肌梗死组和心肌梗死-糖尿病组。从研究参与者身上收集的血液样本进行了各种生化测试，并监测了他们的临床参数。MTHFR C677T （rs1801133）基因分型采用预先确定引物的Tetra ARMS PCR进行。在参与者中，MTHFR C677T （rs1801133）多态性与DM存在时的MI相关。MTHFR C677T (rs1801133) T/T纯合基因型在存在DM的心肌梗死患者中作为危险因素具有显著意义。
Myocardial infarction (MI) is a cardiovascular disease that occurs due to the blockage of the coronary artery. Subsequently, cardiac muscles receive a lower oxygen supply, which leads to the death of cardiac muscles. The etiology of MI is linked to various environmental, occupational, and genetic factors. Various studies have been conducted on the polymorphism of genes involved in MI. Previous studies have shown that different variants of the methylene tetrahydrofolate reductase (MTHFR) gene are involved in causing MI by altering the metabolism of folate and homocysteine. However, the genetic polymorphism of MTHFR C677T (rs1801133) and its association with MI in the presence of diabetes mellitus (DM) as a risk factor still needs to be investigated. This study recruited 300 participants who were divided into three groups, i.e., the control, MI, and MI-DM. The blood samples collected from the study participants were subjected to various biochemical tests and their clinical parameters were monitored. MTHFR C677T (rs1801133) genotyping was performed by Tetra ARMS PCR using predetermined primers. The MTHFR C677T (rs1801133) polymorphism was associated with MI in the presence of DM as a risk factor among the participants. The MTHFR C677T (rs1801133) T/T homozygous genotype was found to be significant among MI patients in the presence of DM as a risk factor.
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