The diversification of the LIM superclass at the base of the metazoa increased subcellular complexity and promoted multicellular specialization.
The diversification of the LIM superclass at the base of the metazoa increased subcellular complexity and promoted multicellular specialization.
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DOI：
10.1371/journal.pone.0033261
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Baxevanis AD
中科院分区：
文献类型：
--
作者：
Koch BJ;Ryan JF;Baxevanis AD
在整个进化过程中，LIM结构域以许多不同的结构域配置进行部署，这导致形成了一个庞大而独特的蛋白质组。LIM蛋白参与将在细胞表面接收的刺激传递到细胞核，以调节细胞结构、运动性和分裂。尽管它们在细胞过程和人类疾病中起着重要作用，但人们对LIM超类的进化知之甚少。我们已经确定并表征了所有已知的LIM结构域的蛋白质在六个后生动物和三个非后生动物。此外，我们对所有LIM结构域进行了系统发育分析，并在此过程中，在这些蛋白质中发现了一些新的非LIM结构域和基序。基于这些结果，我们已经正式的LIM蛋白质的分类系统，提供合理的时间类和家庭的起源事件，并确定特定的谱系损失事件。我们的分析是第一次详细描述的全套LIM蛋白质从非bilaterian物种在这项研究中检查。14个LIM类中的6个起源于后生动物的干谱系。在后生动物的基础上，LIM超纲的扩张无疑有助于从单细胞到多细胞生活方式的转变所需的亚细胞复杂性的增加，因此，这是动物多细胞历史上的一个至关重要的事件。
Throughout evolution, the LIM domain has been deployed in many different domain configurations, which has led to the formation of a large and distinct group of proteins. LIM proteins are involved in relaying stimuli received at the cell surface to the nucleus in order to regulate cell structure, motility, and division. Despite their fundamental roles in cellular processes and human disease, little is known about the evolution of the LIM superclass. We have identified and characterized all known LIM domain-containing proteins in six metazoans and three non-metazoans. In addition, we performed a phylogenetic analysis on all LIM domains and, in the process, have identified a number of novel non-LIM domains and motifs in each of these proteins. Based on these results, we have formalized a classification system for LIM proteins, provided reasonable timing for class and family origin events; and identified lineage-specific loss events. Our analysis is the first detailed description of the full set of LIM proteins from the non-bilaterian species examined in this study. Six of the 14 LIM classes originated in the stem lineage of the Metazoa. The expansion of the LIM superclass at the base of the Metazoa undoubtedly contributed to the increase in subcellular complexity required for the transition from a unicellular to multicellular lifestyle and, as such, was a critically important event in the history of animal multicellularity.
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影响因子：
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