Baf60c is a component of the neural progenitor-specific BAF complex in developing retina.
Baf60c is a component of the neural progenitor-specific BAF complex in developing retina.
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DOI：
10.1002/dvdy.21697
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发表时间：
2008-10
影响因子：
2.5
通讯作者：
Reh, Thomas
中科院分区：
文献类型：
--
作者：
Lamba, Deepak A.;Hayes, Susan;Karl, Mike O.;Reh, Thomas
染色质网络的重构在调节胚胎发育和分化中起着重要作用。SWI/SNF复合物是ATP依赖的染色质重塑复合物。它由几种蛋白质组成，包括一个ATP酶亚基，Brg 1或Brm。该复合物的两个亚基Baf 53 a和Baf 45先前已被鉴定为是神经祖细胞特异性的。在这项研究中，我们表明，Baf 60 c，这个大的复杂的另一个重要组成部分，以类似的神经祖细胞特异性方式发挥作用。我们表明，在发展过程中，Baf 60 c在人类视网膜以及小鼠视网膜，皮层和脊髓的神经祖细胞中表达。Baf 60 c表达在神经分化过程中丢失，并且其过表达通过其与Notch途径的相互作用使祖细胞保持在增殖状态。最后，我们发现Baf 60 c在神经毒性损伤后重新进入细胞周期的Müller神经胶质细胞中重新表达。
Remodeling of the chromatin network plays an important role regulating embryonic development as well as differentiation. The SWI/SNF complex is an ATP dependent chromatin-remodeling complex. It consists of several proteins, including an ATPase subunit, either Brg1 or Brm. Two subunits of this complex Baf53a and Baf45 have been previously identified as being neural progenitor specific. In this study, we show that Baf60c, another important part of this large complex, acts in a similar neural-progenitor specific manner. We show that during development Baf60c is expressed in neural progenitors in human retinas as well as mouse retina, cortex and spinal cord. Baf60c expression is lost during neural differentiation and its over-expression keeps the progenitors in a proliferative state through its interaction with the Notch pathway. Finally, we show that Baf60c is re-expressed in the Müller glial cells that reenter the cell cycle after neurotoxic damage.
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