The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor.
The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor.
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趋化因子（DARC）的Duffy抗原/受体在缺乏红细胞受体的达菲阴性个体的内皮细胞中表达。
DOI：
10.1084/jem.181.4.1311
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发表时间：
1995-04-01
影响因子：
15.3
通讯作者：
Horuk, Richard
中科院分区：
文献类型：
--
作者：
Peiper, Stephen C.;Wang, Zi-Xuan;Neote, Kuldeep;Martin, Alvin W.;Showell, Henry J.;Conklyn, Maryrose J.;Ogborne, Kevin;Hadley, Terrence J.;Lu, Zhao-Hai;Hesselgesser, Joseph;Horuk, Richard
The Duffy antigen/receptor for chemokines (DARC), first identified on erythrocytes, functions not only as a promiscuous chemokine receptor but also as a receptor for the malarial parasite, Plasmodium vivax. The recent finding that DARC is ubiquitously expressed by endothelial cells lining postcapillary venules provides a possible insight into the function of this receptor because this anatomic site is an active interface for leukocyte trafficking. However, the biological significance of DARC is questionable since it has not yet been determined whether individuals lacking the expression of this protein on their erythrocytes (Duffy negative individuals), who are apparently immunologically normal, express the receptor on endothelial cells. However, we report here that DARC is indeed expressed in endothelial cells lining postcapillary venules and splenic sinusoids in individuals who lack the erythrocyte receptor. These findings are based on immunohistochemical, biochemical, and molecular biological analysis of tissues from Duffy negative individuals. We also present data showing that, in contrast to erythrocyte DARC, cells transfected with DARC internalize radiolabeled ligand. We conclude that the DARC may play a critical role in mediating the effects of proinflammatory chemokines on the interactions between leukocyte and endothelial cells since the molecular pathology of the Duffy negative genotype maintains expression on the latter cell type.
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影响因子：
56.9
作者：
MILLER, LH;MASON, SJ;ROTHMAN, IK
通讯作者：
ROTHMAN, IK
白细胞介素2的低亲和力细胞受体。对TAC抗原水平的影响。
影响因子：
15.3
作者：
Robb, R J;Greene, W C;Rusk, C M
通讯作者：
Rusk, C M
影响因子：
2.9
作者：
CHOMCZYNSKI, P;SACCHI, N
通讯作者：
SACCHI, N
影响因子：
56.9
作者：
HOLMES, WE;LEE, J;WOOD, WI
通讯作者：
WOOD, WI
DOI：
10.1073/pnas.91.7.2752
发表时间：
1994-03-29
影响因子：
11.1
作者：
CHARO, IF;MYERS, SJ;COUGHLIN, SR
通讯作者：
COUGHLIN, SR