The Immunology of Stress and the Impact of Inflammation on the Brain and Behavior.
The Immunology of Stress and the Impact of Inflammation on the Brain and Behavior.
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DOI：
10.1192/bja.2020.82
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发表时间：
2021-05
期刊：
影响因子：
1.3
通讯作者：
Michopoulos V
中科院分区：
文献类型：
--
作者：
Ravi M;Miller AH;Michopoulos V
暴露于急性与慢性压力源和威胁分别以适应性和适应不良的方式激活免疫系统。虽然免疫系统响应于威胁的急性激活通过糖皮质激素负反馈进行稳态调节，但由持续应激暴露引起的免疫系统的慢性激活可导致具有炎症素质的非稳态负荷，该炎症素质与应激相关的精神病理学（包括抑郁和焦虑）有关。由慢性应激暴露引起的外周和大脑中的炎症增加可改变神经递质代谢并影响大脑区域的激活，从而增加不良行为健康症状（例如，快感缺乏、焦虑、疲劳）和情绪失调。虽然针对免疫系统及其对大脑的下游影响的干预措施对抑郁症和其他精神疾病的治疗产生了很大的兴趣，因为它们在治疗压力相关的行为健康障碍方面表现出了一定的疗效，但未来的研究需要更好地描述抗炎药应用于治疗压力相关的精神病理学的背景。
Exposure to acute versus chronic stressors and threats activates the immune system in adaptive and maladaptive manners, respectively. While acute activation of the immune system in response to threat is homeostatically regulated by glucocorticoid negative feedback, chronic activation of the immune system arising from persistent stress exposure can contribute to an allostatic load with an inflammatory diathesis that has been implicated in stress-related psychopathology, including of depression and anxiety. Increased inflammation in the periphery and in the brain arising from chronic stress exposure can alter neurotransmitter metabolism and impact activation of brain regions to increase adverse behavioral health symptoms (e.g. anhedonia, anxiety, fatigue) and emotion dysregulation. While interventions targeting the immune system and its downstream effects on the brain for the treatment of depression and other psychiatric disorders has been of great interest as they have shown some efficacy in treating stress-related behavioral health disorders, future studies are necessary to better characterize the contexts under which anti-inflammatory agents should be used to treat stress-related psychopathology.
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影响因子：
25
作者：
Menard C;Pfau ML;Hodes GE;Kana V;Wang VX;Bouchard S;Takahashi A;Flanigan ME;Aleyasin H;LeClair KB;Janssen WG;Labonté B;Parise EM;Lorsch ZS;Golden SA;Heshmati M;Tamminga C;Turecki G;Campbell M;Fayad ZA;Tang CY;Merad M;Russo SJ
通讯作者：
Russo SJ
DOI：
10.1073/pnas.96.3.1059
发表时间：
1999-02-02
影响因子：
11.1
作者：
Dhabhar, FS;McEwen, BS
通讯作者：
McEwen, BS
DOI：
10.1176/appi.focus.20180030
发表时间：
2019-01-01
期刊：
Focus (American Psychiatric Publishing)
影响因子：
--
作者：
Park, Lawrence T;Falodun, Tolulope B;Zarate, Carlos A Jr
通讯作者：
Zarate, Carlos A Jr
影响因子：
4.8
作者：
MILLER, AH;SPENCER, RL;STEIN, M
通讯作者：
STEIN, M
影响因子：
10.6
作者：
Harrison NA;Brydon L;Walker C;Gray MA;Steptoe A;Critchley HD
通讯作者：
Critchley HD