Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation and adhesion molecules.
Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation and adhesion molecules.
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DOI：
10.1038/srep01494
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发表时间：
2013
影响因子：
4.6
通讯作者：
Hughes-Fulford, Millie
中科院分区：
文献类型：
--
作者：
Grenon, S. Marlene;Jeanne, Marion;Aguado-Zuniga, Jesus;Conte, Michael S.;Hughes-Fulford, Millie
包括重力在内的机械力会影响内皮细胞 (EC) 功能，并与血管疾病以及与低重力环境相关的生理变化有关。本研究的目的是调查重力机械卸载对由基因表达模式确定的 EC 表型的影响。将人脐血管内皮细胞暴露于 1 重力环境或机械卸载 (MU) 24 小时，有或没有一段时间的机械加载 (ML)。 MU 导致几种粘附分子和促炎细胞因子的基因表达显着下降。相反，MU 后 eNOS、Caveolin-1 和 -2 的表达显着增加。 MU 使细胞的长度和宽度减少。在MU期间添加ML足以扭转MU引发的变化。我们的结果表明重力负荷可以显着影响血管内皮细胞功能。
Mechanical forces including gravity affect endothelial cell (ECs) function, and have been implicated in vascular disease as well as physiologic changes associated with low gravity environments. The goal of this study was to investigate the impact of gravitational mechanical unloading on ECs phenotype as determined by patterns of gene expression. Human umbilical vascular endothelial cells were exposed to 1-gravity environment or mechanical unloading (MU) for 24 hours, with or without periods of mechanical loading (ML). MU led to a significant decrease in gene expression of several adhesion molecules and pro-inflammatory cytokines. On the contrary, eNOS, Caveolin-1 and -2 expression were significantly increased with MU. There was a decrease in the length and width of the cells with MU. Addition of ML during the MU period was sufficient to reverse the changes triggered by MU. Our results suggest that gravitational loading could dramatically affect vascular endothelial cell function.
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影响因子：
7.2
作者：
Infanger, M.;Kossmehl, P.;Grimm, D.
通讯作者：
Grimm, D.
DOI：
10.1115/1.3138276
发表时间：
1981-01-01
影响因子：
1.7
作者：
DEWEY, CF;BUSSOLARI, SR;DAVIES, PF
通讯作者：
DAVIES, PF
影响因子：
4
作者：
Infanger, Manfred;Ulbrich, Claudia;Grimm, Daniela
通讯作者：
Grimm, Daniela
DOI：
10.1016/j.bbamcr.2005.10.002
发表时间：
2005-12-15
影响因子：
5.1
作者：
Cotrupi, S;Ranzani, D;Maier, JAM
通讯作者：
Maier, JAM
DOI：
10.1016/j.pmr.2005.11.001
发表时间：
2006-02-01
影响因子：
1.7
作者：
Carroll, Kevin
通讯作者：
Carroll, Kevin