Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis.
Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis.
复制标题
COVID-19 后综合症中的疲劳和认知障碍：系统评价和荟萃分析。
DOI：
10.1016/j.bbi.2021.12.020
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
McIntyre RS
中科院分区：
文献类型：
--
作者：
Ceban F;Ling S;Lui LMW;Lee Y;Gill H;Teopiz KM;Rodrigues NB;Subramaniapillai M;Di Vincenzo JD;Cao B;Lin K;Mansur RB;Ho RC;Rosenblat JD;Miskowiak KW;Vinberg M;Maletic V;McIntyre RS
尽管急性感染(即新冠肺炎后综合症)得到缓解，但新冠肺炎仍与临床上的显著症状有关。疲劳和认知障碍是后新冠肺炎综合征最常见和最令人衰弱的症状。量化新冠肺炎确诊后12周或更长时间出现疲劳和认知障碍的个体比例，并表征新冠肺炎后综合征的炎症相关因素和功能后果。从数据库开始到2021年6月8日，在PubMed/MEDLINE、Cochrane图书馆、CogcINFO、Embase、Web of Science、Google/Google Scholar和精选参考列表上进行了无语言限制的系统搜索。选择了在确认新冠肺炎诊断后至少12周对个体进行评估并具体报告疲劳、认知障碍、炎症参数和/或功能结果的主要研究文章。两名评价者独立提取了已发表的摘要数据，并评估了方法学质量和偏倚风险。采用随机效应约束最大似然模型对Freeman-Tukey双反正弦变换后的比例进行Meta分析。共同的主要结果是报告疲劳和认知障碍的个体比例，分别在新冠肺炎感染12周或更长时间后。次要结果是炎症相关因素和与新冠肺炎后综合征相关的功能后果。文献检索产生了10,979项研究，其中81项研究被选为纳入研究。疲劳元分析包括68个研究，认知障碍元分析包括43个研究，48个研究包括在叙事合成中。Meta分析显示，在新冠肺炎确诊后12周或更长时间出现疲劳的个体比例为0.32(95%CI，0.27，0.37；P<；=0.001；n=0.25,268；I2=0.991%)。出现认知障碍的个体比例为0.22(95%CI，0.17，0.28；P<；=0.001；n=0.13,232；I2=0.98.0)。此外，叙事合成显示，在一部分个体中，促炎标志物的升高和相当大的功能障碍。相当大比例的人在急性新冠肺炎缓解后经历持续性疲劳和/或认知障碍。上述症状的频率和衰弱性质为确定潜在的神经生物学底物以及如何最好地治疗这些现象提供了动力。Propero(CRD42021256965)。
COVID-19 is associated with clinically significant symptoms despite resolution of the acute infection (i.e., post-COVID-19 syndrome). Fatigue and cognitive impairment are amongst the most common and debilitating symptoms of post-COVID-19 syndrome. To quantify the proportion of individuals experiencing fatigue and cognitive impairment 12 or more weeks following COVID-19 diagnosis, and to characterize the inflammatory correlates and functional consequences of post-COVID-19 syndrome. Systematic searches were conducted without language restrictions from database inception to June 8, 2021 on PubMed/MEDLINE, The Cochrane Library, PsycInfo, Embase, Web of Science, Google/Google Scholar, and select reference lists. Primary research articles which evaluated individuals at least 12 weeks after confirmed COVID-19 diagnosis and specifically reported on fatigue, cognitive impairment, inflammatory parameters, and/or functional outcomes were selected. Two reviewers independently extracted published summary data and assessed methodological quality and risk of bias. A meta-analysis of proportions was conducted to pool Freeman-Tukey double arcsine transformed proportions using the random-effects restricted maximum-likelihood model. The co-primary outcomes were the proportions of individuals reporting fatigue and cognitive impairment, respectively, 12 or more weeks following COVID-19 infection. The secondary outcomes were inflammatory correlates and functional consequences associated with post-COVID-19 syndrome. The literature search yielded 10,979 studies, and 81 studies were selected for inclusion. The fatigue meta-analysis comprised 68 studies, the cognitive impairment meta-analysis comprised 43 studies, and 48 studies were included in the narrative synthesis. Meta-analysis revealed that the proportion of individuals experiencing fatigue 12 or more weeks following COVID-19 diagnosis was 0.32 (95% CI, 0.27, 0.37; p < 0.001; n = 25,268; I2 = 99.1%). The proportion of individuals exhibiting cognitive impairment was 0.22 (95% CI, 0.17, 0.28; p < 0.001; n = 13,232; I2 = 98.0). Moreover, narrative synthesis revealed elevations in proinflammatory markers and considerable functional impairment in a subset of individuals. A significant proportion of individuals experience persistent fatigue and/or cognitive impairment following resolution of acute COVID-19. The frequency and debilitating nature of the foregoing symptoms provides the impetus to characterize the underlying neurobiological substrates and how to best treat these phenomena. PROSPERO (CRD42021256965).
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影响因子：
3.3
作者：
Ferrucci R;Dini M;Groppo E;Rosci C;Reitano MR;Bai F;Poletti B;Brugnera A;Silani V;D'Arminio Monforte A;Priori A
通讯作者：
Priori A
COVID-19：出院3-6个月后，症状和肺部改变的持久性。
影响因子：
7.5
作者：
Fortini A;Torrigiani A;Sbaragli S;Lo Forte A;Crociani A;Cecchini P;Innocenti Bruni G;Faraone A
通讯作者：
Faraone A
影响因子：
4.4
作者：
Frontera JA;Yang D;Lewis A;Patel P;Medicherla C;Arena V;Fang T;Andino A;Snyder T;Madhavan M;Gratch D;Fuchs B;Dessy A;Canizares M;Jauregui R;Thomas B;Bauman K;Olivera A;Bhagat D;Sonson M;Park G;Stainman R;Sunwoo B;Talmasov D;Tamimi M;Zhu Y;Rosenthal J;Dygert L;Ristic M;Ishii H;Valdes E;Omari M;Gurin L;Huang J;Czeisler BM;Kahn DE;Zhou T;Lin J;Lord AS;Melmed K;Meropol S;Troxel AB;Petkova E;Wisniewski T;Balcer L;Morrison C;Yaghi S;Galetta S
通讯作者：
Galetta S
影响因子：
9.6
作者：
González J;Benítez ID;Carmona P;Santisteve S;Monge A;Moncusí-Moix A;Gort-Paniello C;Pinilla L;Carratalá A;Zuil M;Ferrer R;Ceccato A;Fernández L;Motos A;Riera J;Menéndez R;Garcia-Gasulla D;Peñuelas O;Bermejo-Martin JF;Labarca G;Caballero J;Torres G;de Gonzalo-Calvo D;Torres A;Barbé F;CIBERESUCICOVID Project (COV20/00110, ISCIII)
通讯作者：
CIBERESUCICOVID Project (COV20/00110, ISCIII)
影响因子：
5.2
作者：
Balduzzi, Sara;Ruecker, Gerta;Schwarzer, Guido
通讯作者：
Schwarzer, Guido