Breast cancer by proxy: can the microenvironment be both the cause and consequence?
Breast cancer by proxy: can the microenvironment be both the cause and consequence?
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DOI：
10.1016/j.molmed.2008.11.001
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发表时间：
2009-01
影响因子：
13.6
通讯作者：
Bissell MJ
中科院分区：
文献类型：
--
作者：
Rønnov-Jessen L;Bissell MJ
乳腺癌是实体瘤中最明显的例子之一，其中系统性线索在其发展中起决定性作用。乳腺组织不断受到激素水平的变化和微环境的改变。这种情况在肿瘤发展过程中更加引人注目，因为基底膜（BM）和肌上皮细胞的急剧损失或畸变以及瘤周肌成纤维细胞的增加。我们认为，微环境，在这里定义为所有组成部分的乳腺以外的管腔和/或肿瘤上皮细胞，可能有助于维持器官的完整性和促进，有时甚至启动，乳腺癌的发展。因此，肿瘤微环境及其成分，单独或组合，可能作为有希望的治疗目标。
Breast cancer is one of the most clear-cut examples of a solid tumor in which systemic cues play a decisive part in its development. The breast tissue is constantly subjected to changes in hormone levels and modifications in the microenvironment. This scenario is even more striking during tumor development because of the dramatic loss or aberration of basement membrane (BM) and myoepithelial cells and the gain of peritumoral myofibroblasts. We suggest that the microenvironment, defined here as all components of the mammary gland other than luminal and/or tumor epithelial cells, might be instrumental in maintaining organ integrity and in promoting, and at times even initiating, breast cancer development. As such, the tumor microenvironment and its constituents, alone or in combination, might serve as promising targets for therapy.
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