Learning and aging affect neuronal excitability and learning.
Learning and aging affect neuronal excitability and learning.
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DOI：
10.1016/j.nlm.2019.107133
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发表时间：
2020-01
影响因子：
2.7
通讯作者：
Disterhoft JF
中科院分区：
文献类型：
--
作者：
Oh MM;Disterhoft JF
三十多年前发表的第一项研究表明，在哺乳动物的离体脑组织切片上学习后，神经元的内在兴奋性会发生变化。自从最初的论文发表以来，许多其他的手稿描述了类似的学习相关的变化，这些论文证明了学习延迟眨眼条件反射的兔子的CA1锥体神经元的爆发后超极化（AHP）减少。除了学习相关的变化外，CA1锥体神经元爆发后AHP的衰老相关扩大也有报道。在一些衰老动物中，CA1海马体中缓慢的超极化后增强与缓慢的学习相关的研究已经做了大量的工作。这些可重复的发现强烈暗示，爆发后AHP的调节是成功学习所必需的基本细胞机制，至少在涉及CA1海马锥体神经元的学习任务中是如此。
The first study that demonstrated a change in intrinsic neuronal excitability after learning in ex vivo brain tissue slices from a mammal was published over thirty years ago. Numerous other manuscripts describing similar learning-related changes have followed over the years since the original paper demonstrating the postburst afterhyperpolarization (AHP) reduction in CA1 pyramidal neurons from rabbits that learned delay eyeblink conditioning was published. In addition to the learning-related changes, aging-related enlargement of the postburst AHP in CA1 pyramidal neurons have been reported. Extensive work has been done relating slow afterhyperpolarization enhancement in CA1 hippocampus to slowed learning in some aging animals. These reproducible findings strongly implicate modulation of the postburst AHP as an essential cellular mechanism necessary for successful learning, at least in learning tasks that engage CA1 hippocampal pyramidal neurons.
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影响因子：
2.5
作者：
COULTER, DA;LOTURCO, JJ;ALKON, DL
通讯作者：
ALKON, DL
影响因子：
1.9
作者：
GALLAGHER, M;BURWELL, RD;BURCHINAL, M
通讯作者：
BURCHINAL, M
DOI：
10.1073/pnas.81.24.7956
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
ABRAMS, TW;CASTELLUCCI, VF;LLOYD, PE
通讯作者：
LLOYD, PE
影响因子：
3.8
作者：
CEDAR, H;SCHWARTZ, JH;KANDEL, ER
通讯作者：
KANDEL, ER
影响因子：
5.5
作者：
BLISS, TVP;GARDNERM.AR
通讯作者：
GARDNERM.AR