Health-related quality of life in Japanese patients with prostate cancer following proton beam therapy: an institutional cohort study
Health-related quality of life in Japanese patients with prostate cancer following proton beam therapy: an institutional cohort study
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日本前列腺癌患者质子束治疗后的健康相关生活质量：一项机构队列研究
DOI：
10.1093/jjco/hyaa027
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发表时间：
2020
影响因子：
2.4
通讯作者：
Takamura Noboru
中科院分区：
文献类型：
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作者：
Matsukawa Kyoko;Arimura Takeshi;Orita Makiko;Kondo Hisayoshi;Chuman Ikuko;Ogino Takashi;Taira Yasuyuki;Kudo Takashi;Takamura Noboru
目的许多治疗方案保证了局限性前列腺癌患者的长期生存，与健康相关的生活质量已成为这些患者更加关注的问题。本研究旨在揭示前列腺癌质子治疗后的健康相关生活质量，并阐明与其他治疗方法的差异。方法在2011年1月至2016年4月期间，583名前列腺癌患者纳入研究，使用扩展的前列腺癌指数综合问卷对健康相关生活质量结果进行评估，并与以前针对日本患者的研究进行比较。结果我们发现，质子治疗后除大小便失禁外的尿域和肠域的最小二乘均分显著降低(P<；0.0001)，并在治疗后一年恢复。未接受雄激素剥夺治疗的患者的性功能评分在质子治疗后逐年下降(P<；0.0001)。未去雄激素治疗的患者治疗前激素水平较高，去雄激素治疗的患者治疗前激素水平较低，但治疗2年后与未去雄激素治疗的患者相比差异无统计学意义。发现包括质子治疗在内的放射治疗对患者排尿情况和性功能的影响低于手术治疗。结论首次在日本使用扩展前列腺癌指数综合问卷调查了前列腺癌质子治疗后患者的健康相关生活质量，并与其他治疗方法进行了比较。
ObjectiveMany treatment options have guaranteed long-term survival in patients with localized prostate cancer and health-related quality of life has become a greater concern for those patients. The purpose of this study was to reveal the health-related quality of life after proton beam therapy and to clarify the differences from other treatment modalities for prostate cancer.MethodsBetween January 2011 and April 2016, 583 patients were enrolled in the study and health-related quality of life outcomes using the Expanded Prostate Cancer Index Composite questionnaire were evaluated and compared with previous research targeted at Japanese patients.ResultsWe found a significant decrease in the least square mean scores for urinary and bowel domains excluding the incontinence subscale after proton beam therapy (P< 0.0001) and recovery at a year following treatment. The scores for sexual function in patients without androgen deprivation therapy decreased each year after proton beam therapy (P< 0.0001). The scores for hormones in patients without androgen deprivation therapy remained high and those of patients with androgen deprivation therapy were lower before treatment but were comparable to those of non-androgen deprivation therapy patients at 2 years post-treatment. We found that the impact of radiotherapy including proton beam therapy on urinary condition and sexual function was lower than that of surgery.ConclusionsFor the first time in Japan, we investigated health-related quality of life using Expanded Prostate Cancer Index Composite questionnaires in patients with prostate cancer after proton beam therapy and compared it with other treatment modalities.
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前列腺癌调强放疗后患者的生活质量立即恶化最严重
影响因子：
1.6
作者：
Y. Nakai;N. Tanaka;S. Anai;M. Miyake;I. Asakawa;Y. Morizawa;S. Hori;K. Torimoto;Tomomi Fujii;M. Hasegawa;K. Fujimoto
通讯作者：
K. Fujimoto
影响因子：
19.7
作者：
WILSON, RR
通讯作者：
WILSON, RR
影响因子：
3.6
作者：
Hashine K;Kakuda T;Iuchi S;Hosokawa T;Ninomiya I
通讯作者：
Ninomiya I
影响因子：
3.5
作者：
Yamamoto, Shinya;Fujii, Yasuhisa;Masuda, Hitoshi;Urakami, Shinji;Saito, Kazutaka;Kozuka, Takuyo;Oguchi, Masahiko;Fukui, Iwao;Yonese, Junji
通讯作者：
Yonese, Junji
(10) 卡拉帕亚
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