Transient and steady-state auditory gamma-band responses in first-degree relatives of people with autism spectrum disorder.
Transient and steady-state auditory gamma-band responses in first-degree relatives of people with autism spectrum disorder.
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DOI：
10.1186/2040-2392-2-11
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发表时间：
2011-07-05
期刊：
影响因子：
6.2
通讯作者：
Hepburn S
中科院分区：
文献类型：
--
作者：
Rojas DC;Teale PD;Maharajh K;Kronberg E;Youngpeter K;Wilson LB;Wallace A;Hepburn S
与刺激相关的γ-波段振荡，可能与知觉绑定有关，在自闭症谱系障碍（ASD）患者中减少。本研究的目的是检查ASD患者一级亲属的听觉瞬态和稳态γ-波段结果，以评估这些结果在ASD中的潜在熟悉性。对21名有自闭症谱系障碍（pASD）儿童的父母和20名健康成人对照组（HC）进行了脑磁图（MEG）记录。γ-波段锁相因子（PLF），诱发和诱导功率32，40和48 Hz的调幅声音的瞬态和稳态响应进行了测量。参与者还接受了一些与广泛自闭症表型（BAP）相关的行为和认知评估。主要在稳态反应方面观察到可靠的组间差异。在左半球，pASD受试者在所有三种情况下都表现出较低的锁相稳态功率。在pASD组中，总γ波段功率（包括非锁相分量）也降低。此外，pASD受试者的PLF显著低于HC组。MEG测量和BAP测量之间存在相关性。pASD组中稳态γ-波段反应的降低与ASD儿童的先前结果一致。稳态响应可能比瞬态响应对ASD中的锁相误差更敏感。与一级亲属中较低的PLF和锁相功率一起，γ-带测量与BAP相关的行为测量之间的相关性突出了γ-带缺陷作为潜在的新自闭症内表型的潜力。
Stimulus-related γ-band oscillations, which may be related to perceptual binding, are reduced in people with autism spectrum disorders (ASD). The purpose of this study was to examine auditory transient and steady-state γ-band findings in first-degree relatives of people with ASD to assess the potential familiality of these findings in ASD. Magnetoencephalography (MEG) recordings in 21 parents who had a child with an autism spectrum disorder (pASD) and 20 healthy adult control subjects (HC) were obtained. Gamma-band phase locking factor (PLF), and evoked and induced power to 32, 40 and 48 Hz amplitude-modulated sounds were measured for transient and steady-state responses. Participants were also tested on a number of behavioral and cognitive assessments related to the broad autism phenotype (BAP). Reliable group differences were seen primarily for steady-state responses. In the left hemisphere, pASD subjects exhibited lower phase-locked steady-state power in all three conditions. Total γ-band power, including the non-phase-locked component, was also reduced in the pASD group. In addition, pASD subjects had significantly lower PLF than the HC group. Correlations were seen between MEG measures and BAP measures. The reduction in steady-state γ-band responses in the pASD group is consistent with previous results for children with ASD. Steady-state responses may be more sensitive than transient responses to phase-locking errors in ASD. Together with the lower PLF and phase-locked power in first-degree relatives, correlations between γ-band measures and behavioral measures relevant to the BAP highlight the potential of γ-band deficits as a potential new autism endophenotype.
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影响因子：
4.9
作者：
Gogolla, Nadine;LeBlanc, Jocelyn J.;Quast, Kathleen B.;Sudhof, Thomas C.;Fagiolini, Michela;Hensch, Takao K.
通讯作者：
Hensch, Takao K.
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作者：
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通讯作者：
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11.2
作者：
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通讯作者：
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作者：
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通讯作者：
BOUDREAU, JC