Cooperative Self-Assembly of Lipid–Polymer Hybrids Stabilizing Highly Ordered Bicontinuous Cubic Phases in Air
Cooperative Self-Assembly of Lipid–Polymer Hybrids Stabilizing Highly Ordered Bicontinuous Cubic Phases in Air
复制标题
脂质与聚合物杂化物的协同自组装稳定空气中高度有序的双连续立方相
DOI：
10.1021/acs.macromol.3c00239
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发表时间：
2023
期刊：
影响因子：
5.5
通讯作者：
Leal, Cecilia
中科院分区：
文献类型：
--
作者：
Kang, Minjee;Go, Yoo Kyung;Porras-Gomez, Marilyn;Koulaxizis, Tzortzis;Steer, Dylan;Statt, Antonia;Leal, Cecilia
脂质和嵌段共聚物的共组装是一种使材料具有纳米结构复杂性以及响应传输和机械行为的新策略。在水中，脂质采用多种结构，包括双连续立方相，这对于许多生物技术应用和分离膜是非常理想的。嵌段聚合物组装成类似的中间相，但并不总是需要水介质。利用掠入射小角度x射线散射（GISAXS）和原子力显微镜（AFM），我们发现单油（MO）、1,2-二酰-3-三甲基丙烷（DOTAP）和聚丁二烯-b-环氧乙烷（PBD-b-PEO）在不需要水环境的情况下自组织成高度有序的双连续立方相。三元MO/DOTAP/PBD-b-PEO系统表现出混合双层网络，分离非穿透通道的周期性阵列，保持水分与空气湿度。我们将这种行为归因于带正电的脂质，它们与嵌段共聚物合作，可以固定环境水化，粗粒度模拟证明了这一点。我们的研究拓宽了对脂质-聚合物杂化材料结构多样性的理解，为设计新的生物相容性湿度响应纳米材料开辟了潜力。
The co-assembly of lipids and block copolymers is a new strategy to enable materials with nanostructure complexity as well as responsive transport and mechanical behavior. In water, lipids adopt a variety of structures including bicontinuous cubic phases that are highly desirable for numerous biotechnological applications and separation membranes. Block polymers assemble into analogous mesophases but do not always require aqueous media. Using grazing incidence small-angle X-ray scattering (GISAXS) and atomic force microscopy (AFM), we show that monoolein (MO), 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), and poly(butadiene-b-ethylene oxide) (PBD-b-PEO) self-organize into highly ordered bicontinuous cubic phases without the need of an aqueous environment. Ternary MO/DOTAP/PBD-b-PEO systems exhibit hybrid bilayer networks separating periodic arrays of nonpenetrating channels retaining water from air humidity. We attribute this behavior to positively charged lipids that in cooperation with block copolymers can pin ambient hydration, demonstrated by coarse-grained simulations. Our study broadens the understanding of the structural diversity of lipid–polymer hybrid materials, opening the potential of designing new biocompatible humidity-responsive nanomaterials.
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影响因子：
5.5
作者：
Potter TD;Barrett EL;Miller MA
通讯作者：
Miller MA
使用掠入射小角 X 射线散射控制和分析脂质反双连续立方相的定向薄膜。
影响因子：
3.9
作者：
Martyn Rittman;H. Amenitsch;M. Rappolt;B. Sartori;B. O'driscoll;A. Squires
通讯作者：
A. Squires
影响因子：
10.8
作者：
Bender, J;Ericson, MB;Moan, J
通讯作者：
Moan, J
影响因子：
3.9
作者：
Kowal, Justyna;Wu, Dalin;Meier, Wolfgang
通讯作者：
Meier, Wolfgang
影响因子：
15
作者：
Leal C;Bouxsein NF;Ewert KK;Safinya CR
通讯作者：
Safinya CR