Current State of the First COVID-19 Vaccines.
Current State of the First COVID-19 Vaccines.
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DOI：
10.3390/vaccines9010030
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发表时间：
2021-01-08
期刊：
影响因子：
7.8
通讯作者：
Prüβ BM
中科院分区：
文献类型：
--
作者：
Prüβ BM
2020年，SARS CoV-2及其相关疾病COVID-19肆虐全球。如果大部分人都戴口罩和保持社交距离，可能会有效，但大流行性疲劳降低了它们的功效。经济唐斯伴随着巨大的代价，也不可能是一个长期的解决方案。三家疫苗制造商在11月宣布，他们的疫苗有90%或更高的有效性，至少给那些计划在科学和医学上合理的疫苗上市后立即接种疫苗的人带来了希望。本综述总结了于2020年11月8日进行III期试验的9种疫苗的基本设计策略和开发现状。疫苗生产公司和政府之间的合同旨在将疫苗分发给世界上很大一部分人口。问题仍然是如何运输和/或储存温度敏感的mRNA疫苗，以及如何在每个国家优先接种疫苗。此外，目前的合同并不涵盖所有国家，在非洲和南美洲存在严重差距。本次审查的第二部分将详细介绍目前的分配计划以及疫苗可及性和接受性方面的剩余挑战。
SARS CoV-2 and its associated disease COVID-19 has devastated the world during 2020. Masks and social distancing could be efficient if done by large proportions of the population, but pandemic fatigue has decreased their efficacy. Economic shut downs come with large price tags and cannot be a long term solution either. The announcements by three vaccine manufacturers in November that their vaccines are 90% or more effective has given hope to at least those in the population who plan to get vaccinated as soon as a scientifically and medically sound vaccine becomes available. This review summarizes the underlying design strategies and current status of development of the nine vaccines that were in phase III trial on 8 November 2020. Contracts between vaccine manufacturing companies and governments aim at distributing the vaccine to a large part of the world population. Questions remain how the temperature sensitive mRNA vaccines will be transported and/or stored and how vaccination will be prioritized within each country. Additionally, current contracts do not cover all countries, with a serious gap in Africa and South America. The second part of this review will detail current distribution plans and remaining challenges with vaccine accessibility and acceptance.
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影响因子：
7.8
作者：
Gopalaswamy R;Ganesan N;Velmurugan K;Aravindhan V;Subbian S
通讯作者：
Subbian S
影响因子：
5.5
作者：
Guebre-Xabier M;Patel N;Tian JH;Zhou B;Maciejewski S;Lam K;Portnoff AD;Massare MJ;Frieman MB;Piedra PA;Ellingsworth L;Glenn G;Smith G
通讯作者：
Smith G
影响因子：
4.2
作者：
Haider, Najmul;Yavlinsky, Alexei;Kock, Richard
通讯作者：
Kock, Richard
影响因子：
9.2
作者：
Bos R;Rutten L;van der Lubbe JEM;Bakkers MJG;Hardenberg G;Wegmann F;Zuijdgeest D;de Wilde AH;Koornneef A;Verwilligen A;van Manen D;Kwaks T;Vogels R;Dalebout TJ;Myeni SK;Kikkert M;Snijder EJ;Li Z;Barouch DH;Vellinga J;Langedijk JPM;Zahn RC;Custers J;Schuitemaker H
通讯作者：
Schuitemaker H
影响因子：
9.2
作者：
Graham, Simon P.;McLean, Rebecca K.;Lambe, Teresa
通讯作者：
Lambe, Teresa