Selective and graded coding of reward uncertainty by neurons in the primate anterodorsal septal region.
Selective and graded coding of reward uncertainty by neurons in the primate anterodorsal septal region.
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DOI：
10.1038/nn.3398
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发表时间：
2013-06
影响因子：
25
通讯作者：
Hikosaka, Okihide
中科院分区：
文献类型：
--
作者：
Monosov, Ilya E.;Hikosaka, Okihide
自然环境是不确定的。情绪结果的不确定性可以引起焦虑和提高警觉，促进和发出学习机会的信号，调节经济选择，并调节冒险行为。在这里，我们证明了灵长类隔膜前背侧区域(ADS)的一部分神经元主要致力于以高度特定的方式处理不确定性。这些神经元被指示奖赏概率传递的视觉线索(例如25%、50%、75%奖赏)选择性地激活，而对指示特定结果(0%和100%奖赏)的线索不反应。ADS的平均不确定性反应根据奖励不确定性的大小进行分级，并选择性地发出关于奖励而不是惩罚的不确定性信号。ADS中许多神经元编码的关于奖励不确定性的选择性和分级信息，可能是调节目标导向行为的价值和感觉运动相关区域的不确定性调制的基础。
Natural environments are uncertain. Uncertainty of emotional outcomes can induce anxiety and raise vigilance, promote and signal the opportunity for learning, modulate economic choice, and regulate risk seeking. Here we demonstrate that a subset of neurons in the anterodorsal region of the primate septum (ADS) are primarily devoted to processing uncertainty in a highly specific manner. Those neurons were selectively activated by visual cues indicating probabilistic delivery of reward (e.g. 25%, 50%, 75% reward) and did not respond to cues indicating certain outcomes (0% and 100% reward). The average ADS uncertainty response was graded with the magnitude of reward uncertainty, and selectively signaled uncertainty about rewards rather than punishments. The selective and graded information about reward uncertainty encoded by many neurons in the ADS may underlie uncertainty-modulation of value- and sensorimotor- related areas to regulate goal-directed behavior.
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影响因子：
16.2
作者：
O'Neill, Martin;Schultz, Wolfram
通讯作者：
Schultz, Wolfram
影响因子：
16.2
作者：
Preuschoff, Kerstin;Bossaerts, Peter;Quartz, Steven R.
通讯作者：
Quartz, Steven R.
影响因子：
56.9
作者：
Fiorillo, CD;Tobler, PN;Schultz, W
通讯作者：
Schultz, W
影响因子：
16.2
作者：
Ogawa M;van der Meer MA;Esber GR;Cerri DH;Stalnaker TA;Schoenbaum G
通讯作者：
Schoenbaum G
DOI：
10.1523/jneurosci.2614-09.2009
发表时间：
2009-10-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Christopoulos GI;Tobler PN;Bossaerts P;Dolan RJ;Schultz W
通讯作者：
Schultz W