Risk-responsive orbitofrontal neurons track acquired salience.
Risk-responsive orbitofrontal neurons track acquired salience.
复制标题
DOI：
10.1016/j.neuron.2012.11.006
复制
发表时间：
2013-01-23
期刊：
影响因子：
16.2
通讯作者：
Schoenbaum G
中科院分区：
文献类型：
--
作者：
Ogawa M;van der Meer MA;Esber GR;Cerri DH;Stalnaker TA;Schoenbaum G
决策受到不确定性和风险（即方差）的影响。眶额皮质（一个与决策有关的区域）的活动与这些量相关。然而，这一活动可能反映了预期有多种结果（奖励和奖励遗漏）的情况的突出性。为了解决这些问题，研究人员训练大鼠对预测100%、67%、33%或0%奖励的线索做出反应。与先前的报告一致，一些眶额神经元在预期不确定（33%和67%）与特定奖励（100%和0%）时的放电不同。然而，超过90%的这些神经元在100%与0%奖励（或基线）之前或33%与67%奖励之前也以不同的方式发射。这些反应是不一致的风险，但很好地适合与代表性的收购显着性的线索结果和线索无结果的关联强度的总和。因此，这些结果表明，眶额皮质可能调节学习和行为的一种新机制。
Decision-making is impacted by uncertainty and risk (i.e. variance). Activity in the orbitofrontal cortex, an area implicated in decision-making, covaries with these quantities. However, this activity could reflect the heightened salience of situations in which multiple outcomes - reward and reward omission - are expected. To resolve these accounts, rats were trained to respond to cues predicting 100%, 67%, 33%, or 0% reward. Consistent with prior reports, some orbitofrontal neurons fired differently in anticipation of uncertain (33% and 67%) versus certain reward (100% and 0%). However, over 90% of these neurons also fired differently prior to 100% versus 0% reward (or baseline), or prior to 33% versus 67% reward. These responses are inconsistent with risk, but fit well with the representation of acquired salience linked to the sum of cue-outcome and cue-no-outcome associative strengths. Thus, these results suggest a novel mechanism whereby the orbitofrontal cortex might regulate learning and behavior.
登录
查看更多内容
影响因子：
16.2
作者：
Roesch, Matthew R.;Taylor, Adam R.;Schoenbaum, Geoffrey
通讯作者：
Schoenbaum, Geoffrey
影响因子：
3.4
作者：
Chase, E. Alexander;Tait, David S.;Brown, Verity J.
通讯作者：
Brown, Verity J.
影响因子：
7.6
作者：
St Onge, Jennifer R.;Floresco, Stan B.
通讯作者：
Floresco, Stan B.
影响因子：
16.2
作者：
O'Neill, Martin;Schultz, Wolfram
通讯作者：
Schultz, Wolfram
影响因子：
16.2
作者：
Walton, Mark E.;Behrens, Timothy E. J.;Buckley, Mark J.;Rudebeck, Peter H.;Rushworth, Matthew F. S.
通讯作者：
Rushworth, Matthew F. S.