MRI predictors of cognitive change in a diverse and carefully characterized elderly population.
MRI predictors of cognitive change in a diverse and carefully characterized elderly population.
复制标题
DOI：
10.1016/j.neurobiolaging.2010.01.021
复制
发表时间：
2012-01
影响因子：
4.2
通讯作者：
DeCarli, Charles
中科院分区：
文献类型：
--
作者：
Carmichael, Owen;Mungas, Dan;Beckett, Laurel;Harvey, Danielle;Farias, Sarah Tomaszewski;Reed, Bruce;Olichney, John;Miller, Joshua;DeCarli, Charles
老年人认知能力下降的轨迹是异质性的，在广泛的老年人群中预测认知轨迹具有高可靠性的标记物尚未被确定。本研究检查了各种基于MRI的大脑测量的效用，在基线时获得，作为307名不同程度认知障碍的社区居住老年人队列中认知功能领域特异性测量随后下降的预测因素，这些老年人在许多相关人口统计学变量中存在差异，并每年进行评估。心理测量匹配的认知措施被用来评估情景记忆，语义记忆和执行功能。在混合效应回归模型中评估了基线MRI测量（包括脑体积、海马体和白色高信号（WMH））与认知轨迹之间的关系，该模型模拟了MRI对基线认知表现和变化率的影响以及认知基线和变化率的个体间变异性。较大的基线脑容量预测情节记忆的下降速度较慢，较小的WMH体积预测执行功能和语义记忆的下降速度较慢。基线海马体积虽然与基线认知功能密切相关，但不能预测任何认知领域的后续变化。脑结构和组织病理学的基线测量预测了一个多样化和仔细表征的队列中的认知下降率，这表明它们可以提供预先存在的神经病理学损伤或大脑补偿随后神经病理学对认知的影响的能力的概括性测量。传统的MRI测量可能对预测高度异质性老年人群的认知结果有用。
Trajectories of cognitive decline among elderly individuals are heterogeneous, and markers that have high reliability for predicting cognitive trajectories across a broad spectrum of the elderly population have yet to be identified. This study examined the utility of a variety of MRI-based brain measures, obtained at baseline, as predictors of subsequent declines in domain-specific measures of cognitive function in a cohort of 307 community-dwelling elderly individuals with varying degrees of cognitive impairment who were diverse across a number of relevant demographic variables and were evaluated yearly. Psychometrically matched measures of cognition were used to assess episodic memory, semantic memory, and executive function. Relationships between baseline MRI measures, including the volumes of the brain, hippocampus, and white matter hyperintensities (WMH), and cognitive trajectories were assessed in mixed effects regression models that modeled MRI effects on cognitive performance at baseline and rate of change as well as inter-individual variability in cognitive baseline and rate of change. Greater baseline brain volume predicted slower subsequent rate of decline in episodic memory and smaller WMH volume predicted slower subsequent rate of decline in executive function and semantic memory. Baseline hippocampal volume, while strongly related to baseline cognitive function, was not predictive of subsequent change in any of the cognitive domains. Baseline measures of brain structure and tissue pathology predicted rate of cognitive decline in a diverse and carefully-characterized cohort, suggesting that they may provide summary measures of pre-existing neuropathological damage or the capacity of the brain to compensate for the impact of subsequent neuropathology on cognition. Conventional MRI measures may have utility for predicting cognitive outcomes in highly heterogeneous elderly populations.
登录
查看更多内容
对社区老年人认知能力多样性的分析： 个体差异随年龄的变化而变化
影响因子：
3.7
作者：
Christensen, H;Mackinnon, AJ;Rodgers, B
通讯作者：
Rodgers, B
影响因子：
3.6
作者：
Mungas, D;Reed, BR;González, H
通讯作者：
González, H
影响因子：
3.7
作者：
Albert, MS;Savage, CR;Rowe, JW
通讯作者：
Rowe, JW
影响因子：
2.4
作者：
Mungas, D;Reed, BR;Gonz치lez, HM
通讯作者：
Gonz치lez, HM
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V