Influence of goat colostrum and mature milk on intestinal microbiota

Influence of goat colostrum and mature milk on intestinal microbiota
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山羊初乳和成熟乳对肠道微生物群的影响

DOI:
10.1016/j.jff.2021.104704
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发表时间:
2021-11
影响因子:
5.6
通讯作者:
Zhang Fuxin
Zhang Fuxin
中科院分区:
农林科学2区
文献类型:
--
作者:
Liu Yufang;Cai Junna;Zhang Fuxin

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在本研究中,我们比较了山羊初乳和成熟乳中主要成分的含量,并评估了它们对肠道菌群的影响,以建立乳成分与肠道菌群功能特征之间的相关性。与山羊成熟乳相比,初乳的蛋白质、脂肪、矿物质、干物质、EGF、IGF-I、LTF和IgG含量显着较高,但乳糖和cAMP含量较低。宏基因组分析表明,摄入成熟奶增加了益生菌乳酸杆菌和毛里杆菌的丰度,而摄入山羊初乳不仅可以促进益生菌乳酸杆菌和阿里氏菌的生长,还可以促进致病菌螺杆菌的生长。脂肪含量与螺杆菌丰度呈正相关。我们的研究提供的证据表明,山羊初乳和成熟乳可以以不同的方式改变肠道微生物群落的组成和结构,这可能会驱动对宿主新陈代谢和健康的下游影响。
In this study, we compared the content of main components in goat colostrum and mature milk, and evaluated their influences on the intestinal microbiota to establish the correlations between milk components and functional features of the intestinal microbiota. Compared with goat mature milk, colostrum had significantly higher contents of protein, fat, minerals, dry matter, EGF, IGF-I, LTF and IgG, but lower concentrations of lactose and cAMP. The metagenomic analysis indicated that ingestion of mature milk increased the abundance of probiotic bacteriaLactobacillusandMuribaculum,while goat colostrum intake could promote the growth of probioticsLactobacillusandAlistipes, but also the pathogenHelicobacter. Fat content was positively associated with the abundance ofHelicobacter. Our study provided evidence that goat colostrum and mature milk could change the composition and structure of the intestinal microbiota community in different ways, which might drive the downstream effects on the host’s metabolism and health.
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