Preeclampsia Emerging as a Novel Risk Factor for Cardiovascular Disease in the Offspring.
Preeclampsia Emerging as a Novel Risk Factor for Cardiovascular Disease in the Offspring.
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DOI：
10.2174/1573396316666191224092405
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发表时间：
2020
影响因子：
2
通讯作者：
Dimitriou G
中科院分区：
文献类型：
--
作者：
Karatza AA;Dimitriou G
先兆子痫是一种妊娠期特有疾病，影响所有妊娠的 2%-8%，并与全世界孕产妇、胎儿和新生儿的高发病率和死亡率相关。除了胎儿和胎盘的早产外，这种疾病没有“治愈方法”，然而，先兆子痫对母亲和婴儿来说都是一个长期的健康风险。 该研究的目的是回顾目前可获得的将先兆子痫与婴儿和儿童长期心血管并发症联系起来的信息。 目前，有证据表明先兆子痫母亲所生的孩子易患心血管疾病，且心血管危险因素的发生率较高。在实验模型和人类流行病学研究中，现在都清楚地表明，患有先兆子痫的妊娠婴儿患高血压的风险增加，并且在以后的生活中中风的风险增加一倍。早在 4-10 岁时，先兆子痫就一直与较高的血压和体重指数相关。还有一些证据表明，患有妊娠期高血压疾病的成年人的心血管风险较高。似乎先兆子痫对心血管系统的影响与早产无关，并且与内皮功能障碍、颈动脉内膜中层厚度增加和心脏功能下降有关，而这些不能仅用早产来解释。 考虑到目前现有的证据，现在可以认为先兆子痫与婴儿心脏代谢健康的不利影响有关。了解先兆子痫和心血管疾病之间的关系将有助于实施早期干预措施，以预防或延迟这一高危人群不良事件的发生。
Preeclampsia is a pregnancy specific disorder which affects 2%-8% of all gestations and is associated with high maternal, fetal and neonatal morbidity and mortality worldwide. There is no “cure” for the disease except for early delivery of the fetus and placenta, however leaving preeclampsia a long term health risk both for mothers and infants. The aim of the study is to review currently available information linking preclampsia to long-term cardiovascular complications in infants and children. Currently, there is evidence of predisposition to cardiovascular disease, and a higher incidence of cardiovascular risk factors among children born to preeclamptic mothers. Both in experimental models and human epidemiological studies it is now clear that the infants of pregnancies complicated by preeclampsia have an increased risk of developing high blood pressure and double the risk of stroke in later life. Preeclampsia is consistently associated with higher blood pressure and body mass index as early as 4–10 years of age. Also there is some evidence of higher cardiovascular risk in adults exposed to maternal hypertensive disorders of pregnancy. It seems that preeclampsia has an impact on the cardiovascular system independent of preterm birth and is associated with endothelial dysfunction, increased carotid intima media thickness and reductions in cardiac function that cannot be accounted for by prematurity alone. Taking into consideration the currently available evidence, it can now be suggested that preeclampsia is linked to adverse effects on the cardiometabolic health of the infant. Understanding the relationship between preeclampsia and cardiovascular disease will allow for implementation of early interventions to prevent or delay the onset of adverse events in this high risk population.
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影响因子：
8.3
作者：
Lazdam, Merzaka;de la Horra, Arancha;Leeson, Paul
通讯作者：
Leeson, Paul
DOI：
10.1042/cs20110627
发表时间：
2012-07
期刊：
Clinical science (London, England : 1979)
影响因子：
--
作者：
Davis EF;Newton L;Lewandowski AJ;Lazdam M;Kelly BA;Kyriakou T;Leeson P
通讯作者：
Leeson P
影响因子：
8
作者：
通讯作者：
--
影响因子：
39.3
作者：
Piepoli, Massimo F.;Hoes, Arno W.;Verschuren, W. M. Monique
通讯作者：
Verschuren, W. M. Monique
影响因子：
7.2
作者：
Rice, Madeline Murguia;Landon, Mark B.;Blackwell, Sean C.
通讯作者：
Blackwell, Sean C.