High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children.
High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children.
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DOI：
10.4269/ajtmh.2009.09-0406
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Rowe JA
中科院分区：
文献类型：
--
作者：
Doumbo OK;Thera MA;Koné AK;Raza A;Tempest LJ;Lyke KE;Plowe CV;Rowe JA
恶性疟原虫玫瑰花结（感染红细胞与未感染红细胞的自发结合）是一种公认的寄生虫毒力因子。然而，目前尚不清楚玫瑰花结是否与所有临床形式的严重疟疾相关，或者仅与脑型疟疾等特定综合征相关。我们调查了209名马里儿童中严重疟疾病例对照研究的玫瑰花结和临床疟疾之间的关系。与非严重高寄生虫血症和无并发症疟疾对照相比，严重疟疾病例的寄生虫分离株的玫瑰花结显著更高（F2，117 = 8.15，P < 0.001）。对严重疟疾的亚类（不可唤醒的昏迷、严重贫血、非昏迷性神经功能损害、反复癫痫发作或伴有肾衰竭或黄疸体征的小异质组）的分析显示，所有亚类中的玫瑰花结水平较高，亚类之间的玫瑰花结无统计学显著差异（F4，67 = 1.28，P = 0.28）。因此，玫瑰花结可能有助于非洲儿童所有严重疟疾综合征的发病机制，干扰玫瑰花结的干预措施可能是非洲所有形式严重疟疾的潜在预防性疗法。
Plasmodium falciparum rosetting (the spontaneous binding of infected erythrocytes to uninfected erythrocytes) is a well-recognized parasite virulence factor. However, it is currently unclear whether rosetting is associated with all clinical forms of severe malaria, or only with specific syndromes such as cerebral malaria. We investigated the relationship between rosetting and clinical malaria in 209 Malian children enrolled in a case-control study of severe malaria. Rosetting was significantly higher in parasite isolates from severe malaria cases compared with non-severe hyperparasitemia and uncomplicated malaria controls (F2,117 = 8.15, P < 0.001). Analysis of sub-categories of severe malaria (unrousable coma, severe anemia, non-comatose neurological impairment, repeated seizures or a small heterogeneous group with signs of renal failure or jaundice) showed high levels of rosetting in all sub-categories, and no statistically significant differences in rosetting between sub-categories (F4,67 = 1.28, P = 0.28). Thus rosetting may contribute to the pathogenesis of all severe malaria syndromes in African children, and interventions to disrupt rosetting could be potential adjunctive therapies for all forms of severe malaria in Africa.
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影响因子：
3.5
作者：
Fry AE;Griffiths MJ;Auburn S;Diakite M;Forton JT;Green A;Richardson A;Wilson J;Jallow M;Sisay-Joof F;Pinder M;Peshu N;Williams TN;Marsh K;Molyneux ME;Taylor TE;Rockett KA;Kwiatkowski DP
通讯作者：
Kwiatkowski DP
影响因子：
2.1
作者：
Barragan, A;Spillmann, D;Carlson, J
通讯作者：
Carlson, J
DOI：
10.4269/ajtmh.2007.77.943
发表时间：
2007-11-01
影响因子：
3.3
作者：
Arman, Monica;Raza, Ahmed;Rowe, J. Alexandra
通讯作者：
Rowe, J. Alexandra
影响因子：
6.5
作者：
NASH, GB;COOKE, BM;WAHLGREN, M
通讯作者：
WAHLGREN, M
影响因子：
4.9
作者：
Kyriacou, Helen M.;Steen, Katie E.;Rowe, J. Alexandra
通讯作者：
Rowe, J. Alexandra