Age-dependent plasticity in the superior temporal sulcus in deaf humans: a functional MRI study.
Age-dependent plasticity in the superior temporal sulcus in deaf humans: a functional MRI study.
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DOI：
10.1186/1471-2202-5-56
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发表时间：
2004-12-08
期刊：
影响因子：
2.4
通讯作者：
Itoh H
中科院分区：
文献类型：
--
作者：
Sadato N;Yamada H;Okada T;Yoshida M;Hasegawa T;Matsuki K;Yonekura Y;Itoh H
手语理解激活聋人的听觉皮层。目前还不清楚颞叶皮层的这种功能可塑性是否与年龄有关。我们对6名2岁以下听力损失的聋人手语者、5名听力损失时年龄>5岁的聋人手语者和6名听力正常的手语者进行了功能磁共振成像。任务是日语手语的句子理解。符号理解任务激活了早期和晚期耳聋受试者的颞平面，但没有听到签名者。在早期聋的科目，中上级颞沟激活更显着比晚期聋的科目。由于中上级颞沟是已知的选择性地响应人类的声音，我们的研究结果表明，这个分区的大脑皮层，当被剥夺了适当的输入，可能会作出功能转变，从人类的语音处理视觉处理在一个年龄依赖的方式。
Sign-language comprehension activates the auditory cortex in deaf subjects. It is not known whether this functional plasticity in the temporal cortex is age dependent. We conducted functional magnetic-resonance imaging in six deaf signers who lost their hearing before the age of 2 years, five deaf signers who were >5 years of age at the time of hearing loss and six signers with normal hearing. The task was sentence comprehension in Japanese sign language. The sign-comprehension tasks activated the planum temporale of both early- and late-deaf subjects, but not that of hearing signers. In early-deaf subjects, the middle superior temporal sulcus was more prominently activated than in late-deaf subjects. As the middle superior temporal sulcus is known to respond selectively to human voices, our findings suggest that this subregion of the auditory-association cortex, when deprived of its proper input, might make a functional shift from human voice processing to visual processing in an age-dependent manner.
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影响因子：
56.9
作者：
Calvert, GA;Bullmore, ET;David, AS
通讯作者：
David, AS
影响因子：
1
作者：
Eleweke, CJ;Rodda, M
通讯作者：
Rodda, M
影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
影响因子：
14.5
作者：
Okazawa, H;Naito, Y;Konishi, J
通讯作者：
Konishi, J
DOI：
10.1073/pnas.97.25.13961
发表时间：
2000-12-05
影响因子：
11.1
作者：
Petitto, LA;Zatorre, RJ;Evans, AC
通讯作者：
Evans, AC