Functional Nanoparticles for Enhanced Cancer Therapy.
Functional Nanoparticles for Enhanced Cancer Therapy.
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DOI：
10.3390/pharmaceutics14081682
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发表时间：
2022-08-12
期刊：
影响因子：
5.4
通讯作者：
Wu, Song
中科院分区：
文献类型：
--
作者：
Li, Chenchen;Li, Yuqing;Li, Guangzhi;Wu, Song
癌症是全世界人民死亡的主要原因。传统的治疗方法主要是以化疗为主，化疗有一系列的副作用。与传统的化疗药物相比，基于纳米颗粒的抗癌药物递送具有一些吸引人的特点。纳米技术在生物医学领域的跨学科应用使得功能性纳米颗粒在癌症治疗中取得了很大进展。纳米颗粒已参与癌症的诊断和靶向和个性化治疗。例如，不同的纳米药物策略，包括内源性和外源性刺激响应，表面缀合和纳米药物系统的大分子包封，已经成功地阻止了肿瘤的进展。随着纳米技术的快速发展，功能纳米颗粒的前景广阔。然而，仍然存在一些需要考虑的挑战和限制。在此基础上，本文对功能性纳米粒子在肿瘤治疗中的研究进展进行了分析。研究差距和有前途的临床应用策略进行了讨论。
Cancer is the leading cause of death in people worldwide. The conventional therapeutic approach is mainly based on chemotherapy, which has a series of side effects. Compared with traditional chemotherapy drugs, nanoparticle-based delivery of anti-cancer drugs possesses a few attractive features. The application of nanotechnology in an interdisciplinary manner in the biomedical field has led to functional nanoparticles achieving much progress in cancer therapy. Nanoparticles have been involved in the diagnosis and targeted and personalized treatment of cancer. For example, different nano-drug strategies, including endogenous and exogenous stimuli-responsive, surface conjugation, and macromolecular encapsulation for nano-drug systems, have successfully prevented tumor procession. The future for functional nanoparticles is bright and promising due to the fast development of nanotechnology. However, there are still some challenges and limitations that need to be considered. Based on the above contents, the present article analyzes the progress in developing functional nanoparticles in cancer therapy. Research gaps and promising strategies for the clinical application are discussed.
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