Severe aplastic anemia after COVID-19 mRNA vaccination: Causality or coincidence?
Severe aplastic anemia after COVID-19 mRNA vaccination: Causality or coincidence?
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DOI：
10.1016/j.jaut.2021.102782
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发表时间：
2022-01
影响因子：
12.8
通讯作者：
Sonoki T
中科院分区：
文献类型：
--
作者：
Tabata S;Hosoi H;Murata S;Takeda S;Mushino T;Sonoki T
据报道，在COVID-19感染或接种疫苗后，会出现各种自身免疫性疾病。然而，还没有建立评估疫苗与自身免疫性疾病发展之间关系的方法。再生障碍性贫血（AA）是一种免疫介导的骨髓衰竭综合征。我们报告了一例严重AA病例，该病例是在接种COVID-19疫苗（Pfizer-BioNTech mRNA疫苗）后出现的，并通过异基因造血干细胞移植（HSCT）进行治疗。在该患者中，在HSCT前后均检测到针对SARS-CoV-2刺突蛋白的抗体。在患者的造血干细胞通过HSCT置换后，尽管存在抗SARS-CoV-2抗体，但他的AA有所改善。在这种情况下，来自COVID-19疫苗的抗体可能没有直接参与AA的发展。本病例提示，在同种异体造血干细胞移植前后检测疫苗抗体滴度，可能为疫苗相关自身免疫性疾病的发病机制提供线索。虽然在这种情况下因果关系没有得到证明，但需要进一步评价，以评估疫苗和AA之间的关联。
The development of various autoimmune diseases has been reported after COVID-19 infections or vaccinations. However, no method for assessing the relationships between vaccines and the development of autoimmune diseases has been established. Aplastic anemia (AA) is an immune-mediated bone marrow failure syndrome. We report a case of severe AA that arose after the administration of a COVID-19 vaccine (the Pfizer-BioNTech mRNA vaccine), which was treated with allogeneic hematopoietic stem cell transplantation (HSCT). In this patient, antibodies against the SARS-CoV-2 spike protein were detected both before and after the HSCT. After the patient's hematopoietic stem cells were replaced through HSCT, his AA improved despite the presence of anti-SARS-CoV-2 antibodies. In this case, antibodies derived from the COVID-19 vaccine may not have been directly involved in the development of AA. This case suggests that the measurement of vaccine antibody titers before and after allogeneic HSCT may provide clues to the pathogenesis of vaccine-related autoimmune diseases. Although causality was not proven in this case, further evaluations are warranted to assess the associations between vaccines and AA.
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影响因子：
10.4
作者：
Radwi, Mansoor;Farsi, Sara
通讯作者：
Farsi, Sara
影响因子：
12.8
作者：
Vuille-Lessard É;Montani M;Bosch J;Semmo N
通讯作者：
Semmo N
影响因子：
20.3
作者：
Arepally GM;Ortel TL
通讯作者：
Ortel TL
影响因子：
6.5
作者：
Viallard, JF;Boiron, JM;Pellegrin, JL
通讯作者：
Pellegrin, JL
DOI：
10.1056/nejmra1413485
发表时间：
2018-10-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Young NS
通讯作者：
Young NS