Outdoor air pollution, preterm birth, and low birth weight: analysis of the world health organization global survey on maternal and perinatal health.
Outdoor air pollution, preterm birth, and low birth weight: analysis of the world health organization global survey on maternal and perinatal health.
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DOI：
10.1289/ehp.1306837
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发表时间：
2014-04
影响因子：
10.4
通讯作者：
Souza JP
中科院分区：
文献类型：
--
作者：
Fleischer NL;Merialdi M;van Donkelaar A;Vadillo-Ortega F;Martin RV;Betran AP;Souza JP
背景：吸入细颗粒物(直径为≤2.5μm的颗粒物；PM2.5)可诱发氧化应激和炎症，并可能导致早产和其他不良围产儿结局。目的：在2004年至2008年世界卫生组织母婴健康全球调查的22个国家中，我们调查了室外PM2.5是否与不良出生结局有关。方法：将室外PM2.5的长期平均值(2001-2006年)的估计值分配到发生分娩的每个卫生诊所周围50公里半径的环形缓冲区中。我们使用广义估计方程来确定个人层面的临床水平PM2.5水平与早产和低出生体重之间的关联，调整了个人、诊所和国家层面的季节性和潜在混杂因素。还对国别协会进行了调查。结果：在所有国家中，调整季节性因素后，PM2.5与早产无关，但与低出生体重相关[优势比(OR)=1.22；95%CI：1.07，1.39与第一个四分位数(<；6.3μg/m3)相比，第四个四分位数(>；20.2μg/m~3)]。在PM2.5值范围最大的国家中国，早产和低出生体重儿都只与PM2.5值的最高四分位数有关，这表明可能存在阈值效应(与≥相比，早产和低出生体重PM2.5值分别为36.5μg/m~3和12.5μg/m~3，OR=2.54；CI：1.42，4.55和OR=1.99；结论：室外PM2.5浓度与低出生体重有关，但与早产无关。在像中国这样的快速发展国家，空气污染水平最高可能会影响到这两种结果。引文：Fleischer NL，Merialdi M，van Donkelaar A，Vadillo-Ortega F，Martin RV，Betran AP，Souza JP，O‘Neill女士，2014。户外空气污染、早产和低出生体重：世界卫生组织母婴健康全球调查分析。环境健康展望122:425–430； http://dx.doi.org/10.1289/ehp.1306837
Background: Inhaling fine particles (particulate matter with diameter ≤ 2.5 μm; PM2.5) can induce oxidative stress and inflammation, and may contribute to onset of preterm labor and other adverse perinatal outcomes. Objectives: We examined whether outdoor PM2.5 was associated with adverse birth outcomes among 22 countries in the World Health Organization Global Survey on Maternal and Perinatal Health from 2004 through 2008. Methods: Long-term average (2001–2006) estimates of outdoor PM2.5 were assigned to 50-km–radius circular buffers around each health clinic where births occurred. We used generalized estimating equations to determine associations between clinic-level PM2.5 levels and preterm birth and low birth weight at the individual level, adjusting for seasonality and potential confounders at individual, clinic, and country levels. Country-specific associations were also investigated. Results: Across all countries, adjusting for seasonality, PM2.5 was not associated with preterm birth, but was associated with low birth weight [odds ratio (OR) = 1.22; 95% CI: 1.07, 1.39 for fourth quartile of PM2.5 (> 20.2 μg/m3) compared with the first quartile (< 6.3 μg/m3)]. In China, the country with the largest PM2.5 range, preterm birth and low birth weight both were associated with the highest quartile of PM2.5 only, which suggests a possible threshold effect (OR = 2.54; CI: 1.42, 4.55 and OR = 1.99; CI: 1.06, 3.72 for preterm birth and low birth weight, respectively, for PM2.5 ≥ 36.5 μg/m3 compared with PM2.5 < 12.5 μg/m3). Conclusions: Outdoor PM2.5 concentrations were associated with low birth weight but not preterm birth. In rapidly developing countries, such as China, the highest levels of air pollution may be of concern for both outcomes. Citation: Fleischer NL, Merialdi M, van Donkelaar A, Vadillo-Ortega F, Martin RV, Betran AP, Souza JP, O´Neill MS. 2014. Outdoor air pollution, preterm birth, and low birth weight: analysis of the World Health Organization Global Survey on Maternal and Perinatal Health. Environ Health Perspect 122:425–430; http://dx.doi.org/10.1289/ehp.1306837
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DOI：
10.1186/1476-069x-11-40
发表时间：
2012-06-18
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Kloog I;Melly SJ;Ridgway WL;Coull BA;Schwartz J
通讯作者：
Schwartz J
影响因子：
37.8
作者：
Park, Sung Kyun;O'Neill, Marie S.;Schwartz, Joel
通讯作者：
Schwartz, Joel
影响因子：
4.4
作者：
Levy, Robert C.;Remer, Lorraine A.;Dubovik, Oleg
通讯作者：
Dubovik, Oleg
影响因子：
5
作者：
Chang, Howard H.;Reich, Brian J.;Miranda, Marie Lynn
通讯作者：
Miranda, Marie Lynn
影响因子：
10.4
作者：
Lee SJ;Serre ML;van Donkelaar A;Martin RV;Burnett RT;Jerrett M
通讯作者：
Jerrett M