Internally generated reactivation of single neurons in human hippocampus during free recall.
Internally generated reactivation of single neurons in human hippocampus during free recall.
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DOI：
10.1126/science.1164685
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发表时间：
2008-10-03
期刊：
影响因子：
--
通讯作者：
Fried I
中科院分区：
文献类型：
--
作者：
Gelbard-Sagiv H;Mukamel R;Harel M;Malach R;Fried I
记忆，即过去事物的痕迹，进入人类意识是人类头脑中最大的谜团之一。虽然识别记忆的神经元基础可以在人类和非人类灵长类动物身上进行实验探索，但自由回忆的研究需要大脑宣布发生了回忆记忆(一种生物体固有的事件，观察者看不见)。在这里，我们报告了当受试者第一次观看由视听序列组成的电影情节时，以及后来当他们自由回忆这些情节时，人类海马体及其周围区域中单个神经元的活动。这些神经元中的一个子集表现出选择性放电，这种放电通常持续整个特定事件并在特定事件之后持续长达12秒。在自由回忆时对这些特定事件的记忆的口头报告之前，有选择地重新激活相同的海马区和内嗅区皮质神经元。我们认为，这种重新激活是一种内部产生的神经元，与人类记忆自发出现的主观体验有关。
The emergence of memory, a trace of things past, into human consciousness is one of the greatest mysteries of the human mind. Whereas the neuronal basis of recognition memory can be probed experimentally in human and nonhuman primates, the study of free recall requires that the mind declare the occurrence of a recalled memory (an event intrinsic to the organism and invisible to an observer). Here, we report the activity of single neurons in the human hippocampus and surrounding areas when subjects first view cinematic episodes consisting of audiovisual sequences and again later when they freely recall these episodes. A subset of these neurons exhibited selective firing, which often persisted throughout and following specific episodes for as long as 12 seconds. Verbal reports of memories of these specific episodes at the time of free recall were preceded by selective reactivation of the same hippocampal and entorhinal cortex neurons. We suggest that this reactivation is an internally generated neuronal correlate for the subjective experience of spontaneous emergence of human recollection.
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影响因子：
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影响因子：
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