Genomic epidemiology reveals multiple introductions of Zika virus into the United States.
Genomic epidemiology reveals multiple introductions of Zika virus into the United States.
复制标题
基因组流行病学揭示了寨卡病毒的多次引入到美国。
DOI：
10.1038/nature22400
复制
发表时间：
2017-06-15
期刊：
影响因子：
64.8
通讯作者：
Andersen KG
中科院分区：
文献类型：
--
作者：
Grubaugh ND;Ladner JT;Kraemer MUG;Dudas G;Tan AL;Gangavarapu K;Wiley MR;White S;Thézé J;Magnani DM;Prieto K;Reyes D;Bingham AM;Paul LM;Robles-Sikisaka R;Oliveira G;Pronty D;Barcellona CM;Metsky HC;Baniecki ML;Barnes KG;Chak B;Freije CA;Gladden-Young A;Gnirke A;Luo C;MacInnis B;Matranga CB;Park DJ;Qu J;Schaffner SF;Tomkins-Tinch C;West KL;Winnicki SM;Wohl S;Yozwiak NL;Quick J;Fauver JR;Khan K;Brent SE;Reiner RC Jr;Lichtenberger PN;Ricciardi MJ;Bailey VK;Watkins DI;Cone MR;Kopp EW 4th;Hogan KN;Cannons AC;Jean R;Monaghan AJ;Garry RF;Loman NJ;Faria NR;Porcelli MC;Vasquez C;Nagle ER;Cummings DAT;Stanek D;Rambaut A;Sanchez-Lockhart M;Sabeti PC;Gillis LD;Michael SF;Bedford T;Pybus OG;Isern S;Palacios G;Andersen KG
寨卡病毒（ZIKV）正在造成与严重先天性综合征有关的前所未有的流行病。2016年7月，美国大陆报告了蚊子传播的寨卡病毒传播，此后，佛罗里达州报告了数百例本地获得性感染。为了深入了解寨卡病毒引入的时间、来源和可能的途径，我们通过对感染患者和埃及伊蚊的寨卡病毒基因组测序，从佛罗里达州首次发现寨卡病毒开始追踪该病毒。我们的研究表明，至少有四种（但可能多达40种）引入导致了佛罗里达州的疫情，而当地传播可能始于2016年春季——比最初发现早了几个月。通过分析监测和遗传数据，我们发现ZIKV在迈阿密的传播区之间移动。我们的分析表明，大多数物种的引进与加勒比地区有关，这一发现得到了从该地区进入迈阿密地区的高发病率和交通量的证实。我们的研究提供了对寨卡病毒如何在新的地区开始传播的理解。
Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital syndromes. In July 2016, mosquito-borne ZIKV transmission was reported in the continental United States and since then, hundreds of locally-acquired infections have been reported in Florida. To gain insights into the timing, source, and likely route(s) of ZIKV introduction, we tracked the virus from its first detection in Florida by sequencing ZIKV genomes from infected patients and Aedes aegypti mosquitoes. We show that at least four introductions, but potentially as many as 40, contributed to the outbreak in Florida and that local transmission likely started in the spring of 2016 - several months before initial detection. By analyzing surveillance and genetic data, we discovered that ZIKV moved among transmission zones in Miami. Our analyses show that most introductions are linked to the Caribbean, a finding corroborated by the high incidence rates and traffic volumes from the region into the Miami area. Our study provides an understanding of how ZIKV initiates transmission in new regions.
登录
查看更多内容
DOI：
10.1126/science.aaf5036
发表时间：
2016-04-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Faria NR;Azevedo RDSDS;Kraemer MUG;Souza R;Cunha MS;Hill SC;Thézé J;Bonsall MB;Bowden TA;Rissanen I;Rocco IM;Nogueira JS;Maeda AY;Vasami FGDS;Macedo FLL;Suzuki A;Rodrigues SG;Cruz ACR;Nunes BT;Medeiros DBA;Rodrigues DSG;Queiroz ALN;da Silva EVP;Henriques DF;da Rosa EST;de Oliveira CS;Martins LC;Vasconcelos HB;Casseb LMN;Simith DB;Messina JP;Abade L;Lourenço J;Alcantara LCJ;de Lima MM;Giovanetti M;Hay SI;de Oliveira RS;Lemos PDS;de Oliveira LF;de Lima CPS;da Silva SP;de Vasconcelos JM;Franco L;Cardoso JF;Vianez-Júnior JLDSG;Mir D;Bello G;Delatorre E;Khan K;Creatore M;Coelho GE;de Oliveira WK;Tesh R;Pybus OG;Nunes MRT;Vasconcelos PFC
通讯作者：
Vasconcelos PFC
DOI：
10.1002/cjs.5550360302
发表时间：
2008-09-01
影响因子：
0.6
作者：
Ferreira, Marco A. R.;Suchard, Marc A.
通讯作者：
Suchard, Marc A.
影响因子：
10.7
作者：
Drummond, Alexei J.;Suchard, Marc A.;Rambaut, Andrew
通讯作者：
Rambaut, Andrew
影响因子：
3.8
作者：
Chouin-Carneiro T;Vega-Rua A;Vazeille M;Yebakima A;Girod R;Goindin D;Dupont-Rouzeyrol M;Lourenço-de-Oliveira R;Failloux AB
通讯作者：
Failloux AB
影响因子：
10.7
作者：
Baele, Guy;Lemey, Philippe;Alekseyenko, Alexander V.
通讯作者：
Alekseyenko, Alexander V.