Macrophage Recognition of Crystals and Nanoparticles.
Macrophage Recognition of Crystals and Nanoparticles.
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DOI：
10.3389/fimmu.2018.00103
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发表时间：
2018
影响因子：
7.3
通讯作者：
Nakayama M
中科院分区：
文献类型：
--
作者：
Nakayama M
吸入二氧化硅、石棉和碳纳米管等外源性晶体会导致肺纤维化和癌症。内源性晶体如尿酸盐、胆固醇和羟基磷灰石分别与痛风、动脉粥样硬化和骨关节炎的发病机制相关。这些晶体相关炎性疾病是由巨噬细胞NLRP 3炎性体激活和细胞死亡触发的。因此，重要的是要了解巨噬细胞如何识别晶体。然而，巨噬细胞不太可能进化获得晶体或最近出现的纳米颗粒特异性受体。最近的几项研究报道，一些晶体颗粒是带负电荷的，并被清道夫受体家族成员以电荷依赖性方式识别。或者，也提出了一种晶体的受体非依赖性吞噬作用的模型。本文综述了巨噬细胞识别晶体和纳米颗粒的机制。
Inhalation of exogenous crystals such as silica, asbestos, and carbon nanotubes can cause lung fibrosis and cancer. Endogenous crystals such as monosodium urate, cholesterol, and hydroxyapatite are associated with pathogenesis of gout, atherosclerosis, and osteoarthritis, respectively. These crystal-associated-inflammatory diseases are triggered by the macrophage NLRP3 inflammasome activation and cell death. Therefore, it is important to understand how macrophages recognize crystals. However, it is unlikely that macrophages have evolutionally acquired receptors specific for crystals or recently emerged nanoparticles. Several recent studies have reported that some crystal particles are negatively charged and are recognized by scavenger receptor family members in a charge-dependent manner. Alternatively, a model for receptor-independent phagocytosis of crystals has also been proposed. This review focuses on the mechanisms by which macrophages recognize crystals and nanoparticles.
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DOI：
10.1084/jem.20151267
发表时间：
2015-08-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bournazos S;DiLillo DJ;Ravetch JV
通讯作者：
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影响因子：
32.4
作者：
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Ravetch JV
影响因子：
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通讯作者：
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影响因子：
82.9
作者：
Flach, Tracy L.;Ng, Gilbert;Shi, Yan
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影响因子：
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作者：
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