Molecular Imaging of Inflammatory Disease.
Molecular Imaging of Inflammatory Disease.
复制标题
炎症性疾病的分子成像。
DOI：
10.3390/biomedicines9020152
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发表时间：
2021-02-04
期刊：
影响因子：
4.7
通讯作者：
McNally LR
中科院分区：
文献类型：
--
作者：
Jones MA;MacCuaig WM;Frickenstein AN;Camalan S;Gurcan MN;Holter-Chakrabarty J;Morris KT;McNally MW;Booth KK;Carter S;Grizzle WE;McNally LR
炎性疾病包括多种高度流行的病症，在严重病例中具有高死亡率，范围从心血管疾病、类风湿性关节炎、慢性阻塞性肺病、移植物抗宿主病、到许多胃肠道病症。许多本身不被认为是炎症的疾病与不同程度的炎症有关。免疫系统和炎症反应的成像是令人感兴趣的，因为它可以洞察疾病的进展和严重程度。临床成像技术，如计算机断层扫描（CT）和磁共振成像（MRI）传统上仅限于解剖信息的可视化;然后，必须从结构异常推断是否存在炎症状态。可用造影剂的改进使得获得功能信息以及解剖信息成为可能。炎症的体内成像最终有助于提高诊断和患者监测的准确性，以实现更好的患者护理。炎症生物标志物的高度特异性分子成像允许早期诊断，以防止不可逆的损伤。成像仪器、靶向示踪剂和造影剂的进步代表了临床前研究的一个快速增长领域，有望快速转化为临床。
Inflammatory diseases include a wide variety of highly prevalent conditions with high mortality rates in severe cases ranging from cardiovascular disease, to rheumatoid arthritis, to chronic obstructive pulmonary disease, to graft vs. host disease, to a number of gastrointestinal disorders. Many diseases that are not considered inflammatory per se are associated with varying levels of inflammation. Imaging of the immune system and inflammatory response is of interest as it can give insight into disease progression and severity. Clinical imaging technologies such as computed tomography (CT) and magnetic resonance imaging (MRI) are traditionally limited to the visualization of anatomical information; then, the presence or absence of an inflammatory state must be inferred from the structural abnormalities. Improvement in available contrast agents has made it possible to obtain functional information as well as anatomical. In vivo imaging of inflammation ultimately facilitates an improved accuracy of diagnostics and monitoring of patients to allow for better patient care. Highly specific molecular imaging of inflammatory biomarkers allows for earlier diagnosis to prevent irreversible damage. Advancements in imaging instruments, targeted tracers, and contrast agents represent a rapidly growing area of preclinical research with the hopes of quick translation to the clinic.
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