Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin.
Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin.
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DOI：
10.1111/j.0105-2896.2009.00886.x
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发表时间：
2010-03
影响因子：
8.7
通讯作者：
Stoitzner P
中科院分区：
文献类型：
--
作者：
Romani N;Clausen BE;Stoitzner P
朗格汉斯细胞（Langerhans cells，LC）是存在于上皮中的抗原呈递树突状细胞（Dendritic cells，DC）。研究得最好的例子是表皮的LC。通过电子显微镜，它们的识别特征是独特的棒状或网球拍状的Birbeck颗粒。表型标志是它们表达C型凝集素受体langerin/CD 207。然而，Langerin也在最近发现的真皮和身体其他组织中的DC群体上表达。这些“真皮朗格兰+树突状细胞”与LC无关。这里不涉及兰杰林阴性真皮DC的复杂区域。在这篇文章中，我们简要地回顾了历史，个体发育和稳态的LC。更强调的是在体内的功能特性的讨论。使用基因工程小鼠的新模型极大地促进了我们对LC在引发针对病原体或肿瘤的适应性免疫应答以及在体内诱导和维持针对自身抗原和无害物质的耐受性中的作用的理解。此外，先天效应器功能越来越被认识到。目前在这一领域的活动进行审查，并考虑未来开发的LC在医学上的可能性，例如，用于改进疫苗。
Langerhans cells (LCs) are antigen-presenting dendritic cells (DCs) that reside in epithelia. The best studied example is the LC of the epidermis. By electron microscopy, their identifying feature is the unique rod- or tennis racket-shaped Birbeck granule. The phenotypic hallmark is their expression of the C-type lectin receptor langerin/CD207. Langerin, however, is also expressed on a recently discovered population of DC in the dermis and other tissues of the body. These ‘dermal langerin+ dendritic cells’ are unrelated to LCs. The complex field of langerin-negative dermal DCs is not dealt with here. In this article, we briefly review the history, ontogeny, and homeostasis of LCs. More emphasis is laid on the discussion of functional properties in vivo. Novel models using genetically engineered mice are contributing tremendously to our understanding of the role of LCs in eliciting adaptive immune responses against pathogens or tumors and in inducing and maintaining tolerance against self antigens and innocuous substances in vivo. Also, innate effector functions are increasingly being recognized. Current activities in this area are reviewed, and possibilities for future exploitation of LC in medicine, e.g. for the improvement of vaccines, are contemplated.
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影响因子：
15.9
作者：
Borkowski, TA;Letterio, JJ;Udey, MC
通讯作者：
Udey, MC
影响因子：
15.3
作者：
Bonifaz, L;Bonnyay, D;Mahnke, K;Rivera, M;Nussenzweig, MC;Steinman, RM
通讯作者：
Steinman, RM
DOI：
10.1084/jem.20071966
发表时间：
2007-12-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bursch LS;Wang L;Igyarto B;Kissenpfennig A;Malissen B;Kaplan DH;Hogquist KA
通讯作者：
Hogquist KA
影响因子：
3.7
作者：
BRAATHEN, LR;THORSBY, E
通讯作者：
THORSBY, E
影响因子：
30.5
作者：
Bedoui, Sammy;Whitney, Paul G.;Heath, William R.
通讯作者：
Heath, William R.