Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation.
Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation.
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DOI：
10.4049/jimmunol.1601424
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发表时间：
2016-12-01
期刊：
影响因子：
--
通讯作者：
Male V
中科院分区：
文献类型：
--
作者：
Cuff AO;Robertson FP;Stegmann KA;Pallett LJ;Maini MK;Davidson BR;Male V
人的肝脏含有大量的NK细胞，这种细胞不存在于血液中。在这项研究中，我们发现这些细胞的特征是一种分子特征，这种分子特征介导了它们在肝脏中的保留。通过检查供体和受体HLA不匹配的肝移植，我们区分了供体肝脏来源和受体来源的白细胞，表明Eomeslo NK细胞自由循环，而Eomeshi NK细胞不能离开肝脏。此外，Eomeshi NK细胞在肝脏中保留长达13年。因此，Eomeshi NK细胞是长寿命的肝驻留细胞。我们继续表明，Eomeslo NK细胞可以在成人生活中从循环中招募，并且循环中的Eomeslo NK细胞能够在类似于肝脏的细胞因子条件下上调介导肝脏保留的Eomeslo和分子。这表明循环NK细胞是它们在肝脏中的对应物的前体。
Human liver contains an Eomeshi population of NK cells that is not present in the blood. In this study, we show that these cells are characterized by a molecular signature that mediates their retention in the liver. By examining liver transplants where donors and recipients are HLA mismatched, we distinguish between donor liver–derived and recipient-derived leukocytes to show that Eomeslo NK cells circulate freely whereas Eomeshi NK cells are unable to leave the liver. Furthermore, Eomeshi NK cells are retained in the liver for up to 13 y. Therefore, Eomeshi NK cells are long-lived liver-resident cells. We go on to show that Eomeshi NK cells can be recruited from the circulation during adult life and that circulating Eomeslo NK cells are able to upregulate Eomes and molecules mediating liver retention under cytokine conditions similar to those in the liver. This suggests that circulating NK cells are a precursor of their liver-resident counterparts.
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DOI：
10.4049/jimmunol.1302765
发表时间：
2014-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Crotta S;Gkioka A;Male V;Duarte JH;Davidson S;Nisoli I;Brady HJ;Wack A
通讯作者：
Wack A
影响因子：
30.5
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Reiner, SL
影响因子：
30.5
作者：
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DOI：
10.1084/jem.20070841
发表时间：
2007-09-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Intlekofer AM;Takemoto N;Kao C;Banerjee A;Schambach F;Northrop JK;Shen H;Wherry EJ;Reiner SL
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Reiner SL
影响因子：
12.8
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Hudspeth K;Donadon M;Cimino M;Pontarini E;Tentorio P;Preti M;Hong M;Bertoletti A;Bicciato S;Invernizzi P;Lugli E;Torzilli G;Gershwin ME;Mavilio D
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