Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapy.
Photosensitizer-conjugated silica-coated gold nanoclusters for fluorescence imaging-guided photodynamic therapy.
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用于荧光成像引导的光动力疗法的光敏剂共轭二氧化硅涂层金纳米团簇。
DOI：
10.1016/j.biomaterials.2013.02.063
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发表时间：
2013-06
期刊：
影响因子：
14
通讯作者：
Chen, Xiaoyuan
中科院分区：
文献类型：
--
作者：
Huang, Peng;Lin, Jing;Wang, Shouju;Zhou, Zhijun;Li, Zhiming;Wang, Zhe;Zhang, Chunlei;Yue, Xuyi;Niu, Gang;Yang, Min;Cui, Daxiang;Chen, Xiaoyuan
多功能治疗诊断学最近已被深入研究，以优化治疗方案的有效性和安全性。在这项工作中，基于二氢卟酚e6（Ce 6）光敏剂共轭的二氧化硅包覆的金纳米团簇（AuNCs@SiO2-Ce 6）的光治疗诊断剂的策略性设计和制备的荧光成像引导的光动力学治疗（PDT）。AuNCs@SiO2-Ce 6显示出以下特征：i）高Ce 6光敏剂负载; ii）在其循环期间没有Ce 6的非特异性释放; iii）显著增强的Ce 6的细胞摄取效率，提供与游离Ce 6相比显著改善的光动力学治疗功效; iv）经由Ce 6的荧光和AuNC的等离子体发光两者的纳米制剂的亚细胞表征; v）荧光成像引导的光动力疗法（PDT）。这种光治疗诊断剂具有良好的稳定性、高的水溶性和溶解性、无细胞毒性和良好的生物相容性，从而促进其生物医学应用，特别是用于多模态光学、CT和光声（PA）成像引导的PDT或声动力学治疗。
Multifunctional theranostics have recently been intensively explored to optimize the efficacy and safety of therapeutic regimens. In this work, a photo-theranostic agent based on chlorin e6 (Ce6) photosensitizer-conjugated silica-coated gold nanoclusters (AuNCs@SiO2-Ce6) is strategically designed and prepared for fluorescence imaging-guided photodynamic therapy (PDT). The AuNCs@SiO2-Ce6 shows the following features: i) high Ce6 photosensitizer loading; ii) no non-specific release of Ce6 during its circulation; iii) significantly enhanced cellular uptake efficiency of Ce6, offering a remarkably improved photodynamic therapeutic efficacy compared to free Ce6; iv) subcellular characterization of the nanoformula via both the fluorescence of Ce6 and plasmon luminescence of AuNCs; v) fluorescence imaging-guided photodynamic therapy (PDT). This photo-theranostics owns good stability, high water dispersibility and solubility, non-cytotoxicity, and good biocompatibility, thus facilitating its biomedical applications, particularly for multi-modal optical, CT and photoacoustic (PA) imaging guided PDT or sonodynamic therapy.
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影响因子：
12.4
作者：
Huang P;Xu C;Lin J;Wang C;Wang X;Zhang C;Zhou X;Guo S;Cui D
通讯作者：
Cui D
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影响因子：
14
作者：
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作者：
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影响因子：
14
作者：
Huang, Peng;Li, Zhiming;Cui, Daxiang
通讯作者：
Cui, Daxiang
影响因子：
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作者：
Beer AJ;Kessler H;Wester HJ;Schwaiger M
通讯作者：
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