The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells.
The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells.
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植物生物碱粉防己碱通过自噬依赖性 Wnt/β-连环蛋白和转移性肿瘤抗原 1 信号传导抑制人类肝癌细胞的转移。
DOI：
10.1186/s13046-018-0678-6
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发表时间：
2018-01-15
期刊：
影响因子：
--
通讯作者：
Li W
中科院分区：
文献类型：
--
作者：
Zhang Z;Liu T;Yu M;Li K;Li W
四兰氨基是一种从中国药草的摩尔（Stephania）摩尔（S.
通过伤口愈合和跨性别曲线来评估侵袭和迁移效应。
四兰氨基通过预防细胞EMT抑制HCC侵袭和迁移。基础机制与四链氨基诱导的人肝细胞自噬密切相关，该机制抑制Wnt/β-catenin途径的活性并降低转移性肿瘤抗原1（MTA1）表达以调节癌症细胞转移。
我们的发现首次表明，四丙氨氨酸在抑制人肝细胞癌转移中起着重要作用，并为四兰氨酸在临床HCC治疗中的应用提供了新的见解。
本文的在线版本（10.1186/S13046-018-0678-6）包含补充材料，可供授权用户使用。
Tetrandrine is a bisbenzylisoquinoline alkaloid isolated from the Chinese medicinal herb Stephania tetrandra S. Moore. We previously demonstrated that tetrandrine exhibits potent antitumor effects in many types of cancer cells. In this study, we investigated the effects of tetrandrine on human hepatocellular carcinoma (HCC) metastasis. The invasion and migration effects were evaluated via wound healing and transwell assays. Immunofluorescence and western blotting analyses were used to investigate the levels of epithelial-mesenchymal transition (EMT)-related protein. A metastasis model was established to investigate the inhibitory effect of tetrandrine on hepatocellular carcinoma metastasis in vivo. Tetrandrine inhibits HCC invasion and migration by preventing cell EMT. The underlying mechanism was closely associated with tetrandrine-induced human liver cell autophagy, which inhibits Wnt/β-catenin pathway activity and decreases metastatic tumor antigen 1 (MTA1) expression to modulate cancer cell metastasis. Our findings demonstrate, for the first time, that tetrandrine plays a significant role in the inhibition of human hepatocellular carcinoma metastasis and provide novel insights into the application of tetrandrine in clinical HCC treatment. The online version of this article (10.1186/s13046-018-0678-6) contains supplementary material, which is available to authorized users.
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影响因子：
5.8
作者：
Kane, Robert C.;Farrell, Ann T.;Pazdur, Richard
通讯作者：
Pazdur, Richard
CS055 (Chidamide/HBI-8000) 是一种新型组蛋白脱乙酰酶抑制剂，可诱导人白血病细胞 G1 期阻滞、ROS 依赖性细胞凋亡和分化
影响因子：
4.1
作者：
Gong, Ke;Xie, Jia;Li, Wenhua
通讯作者：
Li, Wenhua
影响因子：
158.5
作者：
Llovet, Josep M.;Ricci, Sergio;Bruix, Jordi
通讯作者：
Bruix, Jordi
影响因子：
4
作者：
Mathew, Robin;White, Eileen
通讯作者：
White, Eileen
Tetrandrine 通过激活白血病细胞中的 ROS 和 Notch1 信号传导来诱导自噬和分化。
影响因子：
--
作者：
Liu T;Men Q;Wu G;Yu C;Huang Z;Liu X;Li W
通讯作者：
Li W