Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night.
Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night.
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DOI：
10.1016/j.gde.2010.12.008
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发表时间：
2011-02
影响因子：
4
通讯作者：
White, Eileen
中科院分区：
文献类型：
--
作者：
Mathew, Robin;White, Eileen
自噬是细胞消耗自身的一部分以在饥饿和压力下生存的机制。这种自我蚕食限制了细胞死亡和组织炎症，回收了能量和生物合成底物，并清除了受损的蛋白质和细胞器，这些蛋白质和细胞器的积累是有毒的。在正常组织中，自噬介导的损伤缓解可能抑制肿瘤发生，而在晚期肿瘤中，大分子循环可能通过缓冲应激下的代谢需求来支持生存。因此，自噬激活在正常细胞中可能抑制肿瘤的发生，而自噬抑制可能对已建立的肿瘤的治疗有益。自噬支持癌细胞代谢的机制正在慢慢出现。随着人们越来越认识到癌症是一种代谢性疾病，自噬介导的分解代谢如何影响细胞和哺乳动物的代谢和肿瘤生长引起了极大的兴趣。大多数癌症治疗方法诱导自噬，或者在许多靶向治疗中直接通过调节控制自噬的信号通路，或者在细胞毒性治疗中间接。然而，自噬诱导在癌症治疗中的功能后果尚不清楚。更好地了解自噬如何在各种细胞应激下调节细胞代谢及其对肿瘤发生的影响，将有助于制定更好的治疗策略来预防和治疗癌症。
Autophagy is the mechanism by which cells consume parts of themselves to survive starvation and stress. This self-cannibalization limits cell death and tissue inflammation, recycles energy and biosynthetic substrates and removes damaged proteins and organelles, accumulation of which is toxic. In normal tissues, autophagy-mediated damage mitigation may suppress tumorigenesis, while in advanced tumors macromolecular recycling may support survival by buffering metabolic demand under stress. As a result, autophagy-activation in normal cells may suppress tumorigenesis, while autophagy inhibition may be beneficial for therapy of established tumors. The mechanisms by which autophagy supports cancer cell metabolism are slowly emerging. As cancer is being increasingly recognized as a metabolic disease, how autophagy-mediated catabolism impacts cellular and mammalian metabolism and tumor growth is of great interest. Most cancer therapeutics induce autophagy, either directly by modulating signaling pathways that control autophagy in the case of many targeted therapies, or indirectly in the case of cytotoxic therapy. However, the functional consequence of autophagy induction in the context of cancer therapy is not yet clear. A better understanding of how autophagy modulates cell metabolism under various cellular stresses and the consequences of this on tumorigenesis will help develop better therapeutic strategies against cancer prevention and treatment.
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影响因子：
19
作者：
Funderburk SF;Wang QJ;Yue Z
通讯作者：
Yue Z
影响因子：
4.3
作者：
Dang, Chi V.
通讯作者：
Dang, Chi V.
影响因子：
78.5
作者：
Mathew, Robin;Karantza-Wadsworth, Vassiliki;White, Eileen
通讯作者：
White, Eileen
影响因子：
50.3
作者：
Luedde, Tom;Beraza, Naiara;Pasparakis, Manolis
通讯作者：
Pasparakis, Manolis
影响因子：
10.6
作者：
Meijer, Alfred J.;Codogno, Patrice
通讯作者：
Codogno, Patrice