Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells.
Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells.
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Tetrandrine 通过激活白血病细胞中的 ROS 和 Notch1 信号传导来诱导自噬和分化。
DOI：
10.18632/oncotarget.3505
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发表时间：
2015-04-10
期刊：
影响因子：
--
通讯作者：
Li W
中科院分区：
文献类型：
--
作者：
Liu T;Men Q;Wu G;Yu C;Huang Z;Liu X;Li W
全反式维甲酸（ATRA）是治疗急性早幼粒细胞白血病（APL）的分化剂。然而，ATRA的治疗效果具有局限性。粉防己碱是一种具有抗肿瘤作用的传统中药提取物。本研究探讨汉防己甲素对PML-RARα阳性急性早幼粒细胞白血病细胞的作用。粉防己碱在体内抑制肿瘤。它通过触发ROS产生和激活Notch 1信号传导诱导自噬和分化。粉防己碱诱导M5型白血病原代细胞自噬和分化体内结果表明，低浓度的粉防己碱通过激活活性氧和Notch 1信号通路抑制白血病细胞增殖并诱导自噬，进而促进其分化。粉防己碱可能通过诱导白血病细胞分化来治疗APL。
All-trans retinoic acid (ATRA) is a differentiating agent for the treatment of acute promyelocytic leukemia (APL). However, the therapeutic efficacy of ATRA has limitations. Tetrandrine is a traditional Chinese medicinal herb extract with antitumor effects. In this study, we investigated the effects of tetrandrine on human PML-RARα-positive acute promyelocytic leukemia cells. Tetrandrine inhibited tumors in vivo. It induced autophagy and differentiation by triggering ROS generation and activating Notch1 signaling. Tetrandrine induced autophagy and differentiation in M5 type patient primary leukemia cells. The in vivo results indicated that low concentrations of tetrandrine inhibited leukemia cells proliferation and induced autophagy and then facilitated their differentiation, by activating ROS and Notch1 signaling. We suggest that tetrandrine is a potential agent for the treatment of APL by inducing differentiation of leukemia cells.
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20.3
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